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Synergistic transdermal delivery of nanoethosomes embedded in hyaluronic acid nanogels for enhancing photodynamic therapy.
Chen, Yunsheng; Zhang, Zheng; Xin, Yu; Zhou, Rong; Jiang, Kai; Sun, Xiyang; He, Dannong; Song, Jie; Zhang, Yixin.
Afiliación
  • Chen Y; Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, 639 Zhizaoju Road, Shanghai 200011, P.R. China. Zhangzheng958@163.com Zhangyixin6688@163.com.
  • Zhang Z; Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, 639 Zhizaoju Road, Shanghai 200011, P.R. China. Zhangzheng958@163.com Zhangyixin6688@163.com.
  • Xin Y; Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, 639 Zhizaoju Road, Shanghai 200011, P.R. China. Zhangzheng958@163.com Zhangyixin6688@163.com.
  • Zhou R; Department of Orthopedic, Changzheng Hospital, Second Military Medical University, Shanghai, China.
  • Jiang K; Institute of Nano Biomedicine and Engineering, Shanghai Engineering Research Center for Intelligent Instrument for Diagnosis and Therapy, 800 Dongchuan Road, Shanghai Jiao Tong University, Shanghai 200240, P.R. China. sjie@sjtu.edu.cn.
  • Sun X; Hongqiao International Institute of Medicine, Tongren Hospital, School of Medicine, Shanghai Jiao Tong University, 1111 XianXia Road, Shanghai, 200336, China. 732003356@shsmu.edu.cn.
  • He D; Shanghai National Engineering Research Center for Nanotechnology, 245 Jiachuan Road, Shanghai 200237, PR China.
  • Song J; Institute of Nano Biomedicine and Engineering, Shanghai Engineering Research Center for Intelligent Instrument for Diagnosis and Therapy, 800 Dongchuan Road, Shanghai Jiao Tong University, Shanghai 200240, P.R. China. sjie@sjtu.edu.cn.
  • Zhang Y; Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, 639 Zhizaoju Road, Shanghai 200011, P.R. China. Zhangzheng958@163.com Zhangyixin6688@163.com and Shanghai National Engineering Research Center for Nanotechnology, 24
Nanoscale ; 12(28): 15435-15442, 2020 Jul 23.
Article en En | MEDLINE | ID: mdl-32662485
Photodynamic therapy (PDT) is a new therapeutic strategy for hypertrophic scars (HS), but it is limited by low drug utilization. Transdermal delivery based on nanoethosomes (ES) has attracted considerable attention as a potential clinical strategy in PDT treating HS. However, free ES are unsatisfactory due to their instability and non-targeting, which causes non-effective delivery and low drug utilization. Herein, 5-aminolevulinic acid (ALA)-loaded ES (ES-ALA) embedded in hyaluronic acid (HA) meshes (HA/ES-ALA), a novel synergistic transdermal delivery nanogel, are developed for enhancing PDT of HS. HA/ES-ALA has a unique structure and property to protect unilaminar ES-ALA with HA meshes and actively target hypertrophic scar fibroblasts (HSFs) with HA receptors. Both in vitro and in vivo experiments demonstrate that HA/ES-ALA has a remarkable transdermal delivery ability with penetrating channels and a membrane-fusion mechanism. Meanwhile, the synergistic delivery mechanism is visually characterized as three stages: synergistic penetration, targeting aggregation and transmembrane delivery. With the synergistic effect, HA/ES-ALA can realize a targeted transdermal delivery, and significantly improve ALA utilization and enhance PDT efficacy. The results demonstrate an effective transdermal delivery route to enhance therapy for HS as well as other skin diseases.
Asunto(s)

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Fotoquimioterapia Idioma: En Revista: Nanoscale Año: 2020 Tipo del documento: Article

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Fotoquimioterapia Idioma: En Revista: Nanoscale Año: 2020 Tipo del documento: Article