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Discovery of Sulfonamide-Derived Agonists of SOS1-Mediated Nucleotide Exchange on RAS Using Fragment-Based Methods.
Sarkar, Dhruba; Olejniczak, Edward T; Phan, Jason; Coker, Jesse A; Sai, Jiqing; Arnold, Allison; Beesetty, Yugandhar; Waterson, Alex G; Fesik, Stephen W.
Afiliación
  • Sarkar D; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, United States.
  • Olejniczak ET; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, United States.
  • Phan J; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, United States.
  • Coker JA; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, United States.
  • Sai J; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, United States.
  • Arnold A; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, United States.
  • Beesetty Y; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, United States.
  • Waterson AG; Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, United States.
  • Fesik SW; Department of Chemistry, Vanderbilt University, Nashville, Tennessee 37232-0146, United States.
J Med Chem ; 63(15): 8325-8337, 2020 08 13.
Article en En | MEDLINE | ID: mdl-32673492

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Sulfonamidas / Proteínas ras / Proteína SOS1 / Guanosina Trifosfato Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Sulfonamidas / Proteínas ras / Proteína SOS1 / Guanosina Trifosfato Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos