Acid-Activatable Transmorphic Peptide-Based Nanomaterials for Photodynamic Therapy.
Angew Chem Int Ed Engl
; 59(46): 20582-20588, 2020 11 09.
Article
en En
| MEDLINE
| ID: mdl-32687653
ABSTRACT
Inspired by the dynamic morphology control of molecular assemblies in biological systems, we have developed pH-responsive transformable peptide-based nanoparticles for photodynamic therapy (PDT) with prolonged tumor retention times. The self-assembled peptide-porphyrin nanoparticles transformed into nanofibers when exposed to the acidic tumor microenvironment, which was mainly driven by enhanced intermolecular hydrogen bond formation between the protonated molecules. The nanoparticle transformation into fibrils improved their singlet oxygen generation ability and enabled high accumulation and long-term retention at tumor sites. Strong fluorescent signals of these nanomaterials were detected in tumor tissue up to 7â
days after administration. Moreover, the peptide assemblies exhibited excellent anti-tumor efficacy via PDT inâ
vivo. This inâ
situ fibrillar transformation strategy could be utilized to design effective stimuli-responsive biomaterials for long-term imaging and therapy.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Péptidos
/
Fotoquimioterapia
/
Ácidos
/
Nanoestructuras
Límite:
Humans
Idioma:
En
Revista:
Angew Chem Int Ed Engl
Año:
2020
Tipo del documento:
Article
País de afiliación:
Países Bajos