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RAB7L1 Participates in Secondary Brain Injury Induced by Experimental Intracerebral Hemorrhage in Rats.
Tan, Xiaoxing; Wei, Yuchong; Cao, Jie; Wu, Degang; Lai, Niansheng; Deng, Ruming; Li, Haiying; Shen, Haitao; Peng, Ya; Li, Xiang; Chen, Gang.
Afiliación
  • Tan X; Department of Neurosurgery, The Third Affiliated Hospital of Soochow University, Juqian Street, Changzhou, 213003, Jiangsu Province, China.
  • Wei Y; Department of Neurosurgery, The Third Affiliated Hospital of Soochow University, Juqian Street, Changzhou, 213003, Jiangsu Province, China.
  • Cao J; Department of Neurosurgery, The Third Affiliated Hospital of Soochow University, Juqian Street, Changzhou, 213003, Jiangsu Province, China.
  • Wu D; Department of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, 215006, Jiangsu Province, China.
  • Lai N; Department of Neurosurgery, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui Province, China.
  • Deng R; Department of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, 215006, Jiangsu Province, China.
  • Li H; Department of Neurosurgery, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui Province, China.
  • Shen H; Department of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, 215006, Jiangsu Province, China.
  • Peng Y; Department of Neurosurgery, The People's Hospital of Bozhou, Bozhou, Anhui Province, China.
  • Li X; Department of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, 215006, Jiangsu Province, China.
  • Chen G; Department of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, 215006, Jiangsu Province, China.
J Mol Neurosci ; 71(1): 9-18, 2021 Jan.
Article en En | MEDLINE | ID: mdl-32691280
ABSTRACT
RAB7, a member of RAS oncogene family-like 1 (RAB7L1), is a GTPase belonging to the Rab family and acts as an upstream regulator to regulate the kinase activity of leucine-rich repeat kinase 2 (LRRK2). Although LRRK2 has been shown to aggravate secondary brain injury (SBI) after intracerebral hemorrhage (ICH), it is unknown whether RAB7L1 is also involved in this process. The purpose of the present study was to investigate the role of RAB7L1 in ICH-induced SBI in vivo. Autologous blood was injected into adult male Sprague-Dawley rats to induce an ICH model in vivo. The results showed that the protein levels of RAB7L1 increased after ICH. Overexpression of RAB7L1 induced neuronal apoptosis and damage, as demonstrated by TUNEL-positive and FJB-positive cells, and exacerbated ICH-induced learning and cognitive dysfunctions; in contrast, downregulation of RAB7L1 via RNA interference yielded comparatively opposite changes in these parameters. In summary, this study demonstrates that RAB7L1 promotes SBI after ICH and may represent a potential target for ICH therapy.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Daño Encefálico Crónico / Hemorragia Cerebral / Proteínas de Unión al GTP rab / Proteínas del Tejido Nervioso Tipo de estudio: Etiology_studies Idioma: En Revista: J Mol Neurosci Asunto de la revista: BIOLOGIA MOLECULAR / NEUROLOGIA Año: 2021 Tipo del documento: Article País de afiliación: China
Texto completo
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Daño Encefálico Crónico / Hemorragia Cerebral / Proteínas de Unión al GTP rab / Proteínas del Tejido Nervioso Tipo de estudio: Etiology_studies Idioma: En Revista: J Mol Neurosci Asunto de la revista: BIOLOGIA MOLECULAR / NEUROLOGIA Año: 2021 Tipo del documento: Article País de afiliación: China