SARS-CoV-2 and Guillain-Barré syndrome: molecular mimicry with human heat shock proteins as potential pathogenic mechanism.
Cell Stress Chaperones
; 25(5): 731-735, 2020 09.
Article
en En
| MEDLINE
| ID: mdl-32729001
ABSTRACT
Severe acute respiratory syndrome-related coronavirus 2 infection has been associated with Guillain-Barré syndrome. We investigated here the potential mechanism underlying the virus-induced damage of the peripheral nervous systems by searching the viral amino acid sequence for peptides common to human autoantigens associated with immune-mediated polyneuropathies. Our results show molecular mimicry between the virus and human heat shock proteins 90 and 60, which are associated with Guillain-Barré syndrome and other autoimmune diseases. Crucially, the shared peptides are embedded in immunoreactive epitopes that have been experimentally validated in the human host.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Neumonía Viral
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Proteínas Virales
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Infecciones por Coronavirus
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Proteínas HSP90 de Choque Térmico
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Chaperonina 60
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Síndrome de Guillain-Barré
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Proteínas Mitocondriales
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Betacoronavirus
Límite:
Humans
Idioma:
En
Revista:
Cell Stress Chaperones
Año:
2020
Tipo del documento:
Article
País de afiliación:
Alemania