STAT3 serine phosphorylation is required for TLR4 metabolic reprogramming and IL-1ß expression.

Balic, Jesse J; Albargy, Hassan; Luu, Kevin; Kirby, Francis J; Jayasekara, W Samantha N; Mansell, Finbar; Garama, Daniel J; De Nardo, Dominic; Baschuk, Nikola; Louis, Cynthia; Humphries, Fiachra; Fitzgerald, Katherine; Latz, Eicke; Gough, Daniel J; Mansell, Ashley

Balic, Jesse J; Albargy, Hassan; Luu, Kevin; Kirby, Francis J; Jayasekara, W Samantha N; Mansell, Finbar; Garama, Daniel J; De Nardo, Dominic; Baschuk, Nikola; Louis, Cynthia; Humphries, Fiachra; Fitzgerald, Katherine; Latz, Eicke; Gough, Daniel J; Mansell, Ashley.

Afiliación

Balic JJ; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, VIC, 3168, Australia.
Albargy H; Department of Molecular and Translational Sciences, Monash University, Clayton, VIC, 3168, Australia.
Luu K; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, VIC, 3168, Australia.
Kirby FJ; Department of Molecular and Translational Sciences, Monash University, Clayton, VIC, 3168, Australia.
Jayasekara WSN; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, VIC, 3168, Australia.
Mansell F; Department of Molecular and Translational Sciences, Monash University, Clayton, VIC, 3168, Australia.
Garama DJ; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, VIC, 3168, Australia.
De Nardo D; Department of Molecular and Translational Sciences, Monash University, Clayton, VIC, 3168, Australia.
Baschuk N; Department of Molecular and Translational Sciences, Monash University, Clayton, VIC, 3168, Australia.
Louis C; Centre for Cancer Research, Hudson Institute of Medical Research, Clayton, VIC, 3168, Australia.
Humphries F; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, VIC, 3168, Australia.
Fitzgerald K; Department of Molecular and Translational Sciences, Monash University, Clayton, VIC, 3168, Australia.
Latz E; Department of Molecular and Translational Sciences, Monash University, Clayton, VIC, 3168, Australia.
Gough DJ; Centre for Cancer Research, Hudson Institute of Medical Research, Clayton, VIC, 3168, Australia.
Mansell A; Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, 3800, Australia.

Nat Commun ; 11(1): 3816, 2020 07 30.

Article en En | MEDLINE | ID: mdl-32732870

Asunto(s)

Interleucina-1beta/metabolismo; Macrófagos/metabolismo; Factor de Transcripción STAT3/metabolismo; Receptor Toll-Like 4/metabolismo; Animales; Línea Celular; Células Cultivadas; Expresión Génica; Glucólisis/efectos de los fármacos; Inflamación/genética; Inflamación/metabolismo; Interleucina-1beta/genética; Lipopolisacáridos/farmacología; Macrófagos/efectos de los fármacos; Ratones Endogámicos C57BL; Ratones Noqueados; Ratones Transgénicos; Fosforilación; Proteínas Serina-Treonina Quinasas/genética; Proteínas Serina-Treonina Quinasas/metabolismo; Factor de Transcripción STAT3/genética; Serina/genética; Serina/metabolismo; Transducción de Señal/efectos de los fármacos; Transducción de Señal/genética; Factor 6 Asociado a Receptor de TNF/genética; Factor 6 Asociado a Receptor de TNF/metabolismo; Receptor Toll-Like 4/genética

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Factor de Transcripción STAT3 / Receptor Toll-Like 4 / Interleucina-1beta / Macrófagos Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2020 Tipo del documento: Article País de afiliación: Australia

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