Discovery, synthesis and characterization of a series of 7-aryl-imidazo[1,2-a]pyridine-3-ylquinolines as activin-like kinase (ALK) inhibitors.
Bioorg Med Chem Lett
; 30(18): 127418, 2020 09 15.
Article
en En
| MEDLINE
| ID: mdl-32750526
ABSTRACT
The activin-like kinases are a family of kinases that play important roles in a variety of disease states. Of this class of kinases, ALK2, has been shown by a gain-of-function to be the primary driver of the childhood skeletal disease fibrodysplasia ossificans progressiva (FOP) and more recently the pediatric cancer diffuse intrinsic pontine glioma (DIPG). Herein, we report our efforts to identify a novel imidazo[1,2-a]pyridine scaffold as potent inhibitors of ALK2 with good in vivo pharmacokinetic properties suitable for future animal studies.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Quinolinas
/
Receptores de Activinas Tipo I
/
Inhibidores de Proteínas Quinasas
/
Glioma Pontino Intrínseco Difuso
/
Miositis Osificante
Límite:
Animals
/
Child
/
Humans
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2020
Tipo del documento:
Article
País de afiliación:
Estados Unidos