Molecular characterization of an emerging reassortant mammalian orthoreovirus in China.
Arch Virol
; 165(10): 2367-2372, 2020 Oct.
Article
en En
| MEDLINE
| ID: mdl-32757058
Mammalian orthoreoviruses (MRVs) infect almost all mammals, and there are some reports on MRVs in China. In this study, a novel strain was identified, which was designated as HLJYC2017. The results of genetic analysis showed that MRV HLJYC2017 is a reassortant strain. According to biological information analysis, different serotypes of MRV contain specific amino acid insertions and deletions in the σ1 protein. Neutralizing antibody epitope analysis revealed partial cross-protection among MRV1, MRV2, and MRV3 isolates from China. L3 gene recombination in MRV was identified for the first time in this study. The results of this study provide valuable information on MRV reassortment and evolution.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Virus Reordenados
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Infecciones por Reoviridae
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Orthoreovirus de los Mamíferos
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Proteínas de la Cápside
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Antígenos Virales
Límite:
Animals
País/Región como asunto:
Asia
Idioma:
En
Revista:
Arch Virol
Año:
2020
Tipo del documento:
Article
País de afiliación:
China