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Influence of aerobic fitness on gastrointestinal barrier integrity and microbial translocation following a fixed-intensity military exertional heat stress test.
Ogden, Henry B; Fallowfield, Joanne L; Child, Robert B; Davison, Glen; Fleming, Simon C; Delves, Simon K; Millyard, Alison; Westwood, Caroline S; Layden, Joseph D.
Afiliación
  • Ogden HB; Faculty of Sport, Health and Wellbeing, Plymouth MARJON University, Derriford Rd, Plymouth, PL6 8BH, UK. ogden.h@pgr.marjon.ac.uk.
  • Fallowfield JL; Institute of Naval Medicine, Alverstoke, UK.
  • Child RB; School of Chemical Engineering, University of Birmingham, Birmingham, UK.
  • Davison G; Endurance Research Group, School of Sport and Exercise Sciences, University of Kent, Chatham Maritime, UK.
  • Fleming SC; Royal Cornwall NHS Trust, Truro, UK.
  • Delves SK; Institute of Naval Medicine, Alverstoke, UK.
  • Millyard A; Faculty of Sport, Health and Wellbeing, Plymouth MARJON University, Derriford Rd, Plymouth, PL6 8BH, UK.
  • Westwood CS; Faculty of Sport, Health and Wellbeing, Plymouth MARJON University, Derriford Rd, Plymouth, PL6 8BH, UK.
  • Layden JD; Faculty of Sport, Health and Wellbeing, Plymouth MARJON University, Derriford Rd, Plymouth, PL6 8BH, UK.
Eur J Appl Physiol ; 120(10): 2325-2337, 2020 Oct.
Article en En | MEDLINE | ID: mdl-32794058
PURPOSE: Exertional-heat stress adversely disrupts gastrointestinal (GI) barrier integrity, whereby subsequent microbial translocation (MT) can result in potentially serious health consequences. To date, the influence of aerobic fitness on GI barrier integrity and MT following exertional-heat stress is poorly characterised. METHOD: Ten untrained (UT; VO2max = 45 ± 3 ml·kg-1·min-1) and ten highly trained (HT; VO2max = 64 ± 4 ml·kg-1·min-1) males completed an ecologically valid (military) 80-min fixed-intensity exertional-heat stress test (EHST). Venous blood was drawn immediately pre- and post-EHST. GI barrier integrity was assessed using the serum dual-sugar absorption test (DSAT) and plasma Intestinal Fatty-Acid Binding Protein (I-FABP). MT was assessed using plasma Bacteroides/total 16S DNA. RESULTS: UT experienced greater thermoregulatory, cardiovascular and perceptual strain (p < 0.05) than HT during the EHST. Serum DSAT responses were similar between the two groups (p = 0.59), although Δ I-FABP was greater (p = 0.04) in the UT (1.14 ± 1.36 ng·ml-1) versus HT (0.20 ± 0.29 ng·ml-1) group. Bacteroides/Total 16S DNA ratio was unchanged (Δ; -0.04 ± 0.18) following the EHST in the HT group, but increased (Δ; 0.19 ± 0.25) in the UT group (p = 0.05). Weekly aerobic training hours had a weak, negative correlation with Δ I-FABP and Bacteroides/total 16S DNA responses. CONCLUSION: When exercising at the same absolute workload, UT individuals are more susceptible to small intestinal epithelial injury and MT than HT individuals. These responses appear partially attributable to greater thermoregulatory, cardiovascular, and perceptual strain.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Trastornos de Estrés por Calor / Microbioma Gastrointestinal / Capacidad Cardiovascular / Absorción Intestinal Límite: Adult / Humans / Male Idioma: En Revista: Eur J Appl Physiol Asunto de la revista: FISIOLOGIA Año: 2020 Tipo del documento: Article

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Trastornos de Estrés por Calor / Microbioma Gastrointestinal / Capacidad Cardiovascular / Absorción Intestinal Límite: Adult / Humans / Male Idioma: En Revista: Eur J Appl Physiol Asunto de la revista: FISIOLOGIA Año: 2020 Tipo del documento: Article