Novel phthalide derivatives: Synthesis and anti-inflammatory activity in vitro and in vivo.

Chen, Liu Zeng; Wu, Jing; Li, Kang; Wu, Qian Qian; Chen, Rui; Liu, Xin Hua; Ruan, Ban Feng

Novel phthalide derivatives: Synthesis and anti-inflammatory activity in vitro and in vivo.

Chen, Liu Zeng; Wu, Jing; Li, Kang; Wu, Qian Qian; Chen, Rui; Liu, Xin Hua; Ruan, Ban Feng.

Afiliación

Chen LZ; School of Pharmacy, Anhui Medical University, Hefei, 230032, PR China.
Wu J; School of Pharmacy, Anhui Medical University, Hefei, 230032, PR China.
Li K; School of Pharmacy, Anhui Medical University, Hefei, 230032, PR China.
Wu QQ; School of Pharmacy, Anhui Medical University, Hefei, 230032, PR China.
Chen R; School of Pharmacy, Anhui Medical University, Hefei, 230032, PR China.
Liu XH; School of Pharmacy, Anhui Medical University, Hefei, 230032, PR China. Electronic address: xhliuhx@163.com.
Ruan BF; Key Lab of Biofabrication of Anhui Higher Education, Hefei University, Hefei, 230601, PR China. Electronic address: ruanbf@hfuu.edu.cn.

Eur J Med Chem ; 206: 112722, 2020 Nov 15.

Article en En | MEDLINE | ID: mdl-32823004

Asunto(s)

Antiinflamatorios/síntesis química; Antiinflamatorios/farmacología; Benzofuranos/síntesis química; Benzofuranos/farmacología; Animales; Antiinflamatorios/química; Benzofuranos/química; Técnicas de Química Sintética; Concentración 50 Inhibidora; Sistema de Señalización de MAP Quinasas/efectos de los fármacos; Ratones; Factor 2 Relacionado con NF-E2/metabolismo; FN-kappa B/metabolismo; Células RAW 264.7; Especies Reactivas de Oxígeno/metabolismo

Palabras clave

Anti-inflammatory; Design; Phthalide derivatives; Synthesis

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Benzofuranos / Antiinflamatorios Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Eur J Med Chem Año: 2020 Tipo del documento: Article

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