End-Tidal Carbon Dioxide Impacts Brain and Kidney Injury in Experimental Extracorporeal Cardiopulmonary Resuscitation (ECPR).
Shock
; 55(4): 563-569, 2021 04 01.
Article
en En
| MEDLINE
| ID: mdl-32826810
ABSTRACT
PURPOSE:
Extracorporeal membrane oxygenation-assisted cardiopulmonary resuscitation (ECPR) is proposed for cardiac resuscitation in selected cases. End-tidal carbon dioxide (ETCO2) is easily obtained during conventional cardiopulmonary resuscitation (CPR). We hypothesized that the level of ETCO2 during CPR would reflect the degree of brain and kidney damage following ECPR in experimental refractory cardiac arrest.METHODS:
Ventricular fibrillation was induced in 10 pigs, followed by mechanical CPR for 45 min and thereafter ECPR for 180 min. Blood- and urine-samples, physiologic parameters, and histopathology of brain and kidney were analyzed. Animals were divided into Group High (GHigh) and Group Low (GLow) according to value of ETCO2 (10 mm Hg) at the end of CPR.RESULTS:
Carotid blood pressure and blood flow declined over time in both groups during CPR but was higher in GHigh. Coefficient of determination for ETCO2 and carotid blood flow was substantial (r2â=â0.62). The oxygen delivery index was higher for GHigh 444 (396-485) L/min/m2 as compared with GLow at 343 (327-384) L/min/m2 (Pâ=â0.02) at the end of ECPR. Also, P-S100B were lower in GHigh, (Pâ<â0.05) and GLow demonstrated worse histopathological injury in central parts of the brain (Pâ<â0.01). During ECPR, urinary output was higher in GHigh (Pâ<â0.05). Kidney injury marker Plasma Neutrophil Gelatinae-associated Lipocalin increased in both groups during ECPR but was more pronounced in GLow (Pâ=â0.03). Renal histopathology revealed no difference between groups.CONCLUSIONS:
ETCO2 at the end of mechanical CPR is inversely associated with extent of brainstem and renal injury following ECPR.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Lesiones Encefálicas
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Dióxido de Carbono
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Oxigenación por Membrana Extracorpórea
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Reanimación Cardiopulmonar
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Riñón
Límite:
Animals
Idioma:
En
Revista:
Shock
Asunto de la revista:
ANGIOLOGIA
/
CARDIOLOGIA
Año:
2021
Tipo del documento:
Article
País de afiliación:
Suecia