Transcriptomic analysis links diverse hypothalamic cell types to fibroblast growth factor 1-induced sustained diabetes remission.

Bentsen, Marie A; Rausch, Dylan M; Mirzadeh, Zaman; Muta, Kenjiro; Scarlett, Jarrad M; Brown, Jenny M; Herranz-Pérez, Vicente; Baquero, Arian F; Thompson, Jonatan; Alonge, Kimberly M; Faber, Chelsea L; Kaiyala, Karl J; Bennett, Camdin; Pyke, Charles; Ratner, Cecilia; Egerod, Kristoffer L; Holst, Birgitte; Meek, Thomas H; Kutlu, Burak; Zhang, Yu; Sparso, Thomas; Grove, Kevin L; Morton, Gregory J; Kornum, Birgitte R; García-Verdugo, José-Manuel; Secher, Anna; Jorgensen, Rasmus; Schwartz, Michael W; Pers, Tune H

Bentsen, Marie A; Rausch, Dylan M; Mirzadeh, Zaman; Muta, Kenjiro; Scarlett, Jarrad M; Brown, Jenny M; Herranz-Pérez, Vicente; Baquero, Arian F; Thompson, Jonatan; Alonge, Kimberly M; Faber, Chelsea L; Kaiyala, Karl J; Bennett, Camdin; Pyke, Charles; Ratner, Cecilia; Egerod, Kristoffer L; Holst, Birgitte; Meek, Thomas H; Kutlu, Burak; Zhang, Yu; Sparso, Thomas; Grove, Kevin L; Morton, Gregory J; Kornum, Birgitte R; García-Verdugo, José-Manuel; Secher, Anna; Jorgensen, Rasmus; Schwartz, Michael W; Pers, Tune H.

Afiliación

Bentsen MA; UW Medicine Diabetes Institute, University of Washington, Seattle, WA, USA.
Rausch DM; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Mirzadeh Z; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Muta K; Barrow Neurological Institute, Phoenix, AZ, USA.
Scarlett JM; UW Medicine Diabetes Institute, University of Washington, Seattle, WA, USA.
Brown JM; Chakri Naruebodindra Medical Institute, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Herranz-Pérez V; UW Medicine Diabetes Institute, University of Washington, Seattle, WA, USA.
Baquero AF; Department of Pediatric Gastroenterology and Hepatology, Seattle Children's Hospital, Seattle, WA, USA.
Thompson J; UW Medicine Diabetes Institute, University of Washington, Seattle, WA, USA.
Alonge KM; Cavanilles Institute of Biodiversity and Evolutionary Biology, University of Valencia, Valencia, Spain.
Faber CL; Predepartamental Unit of Medicine, Jaume I University, Castelló de la Plana, Spain.
Kaiyala KJ; Obesity Research Unit, Novo Nordisk Research Center Seattle, Inc., Seattle, WA, USA.
Bennett C; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Pyke C; UW Medicine Diabetes Institute, University of Washington, Seattle, WA, USA.
Ratner C; UW Medicine Diabetes Institute, University of Washington, Seattle, WA, USA.
Egerod KL; Department of Oral Health Sciences, School of Dentistry, University of Washington, Seattle, WA, USA.
Holst B; Obesity Research Unit, Novo Nordisk Research Center Seattle, Inc., Seattle, WA, USA.
Meek TH; Pathology & Imaging, Global Discovery and Development Sciences, Novo Nordisk A/S, Maaloev, Denmark.
Kutlu B; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Zhang Y; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Sparso T; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Grove KL; Obesity Research Unit, Novo Nordisk Research Center Seattle, Inc., Seattle, WA, USA.
Morton GJ; Obesity Research Unit, Novo Nordisk Research Center Seattle, Inc., Seattle, WA, USA.
Kornum BR; Obesity Research Unit, Novo Nordisk Research Center Seattle, Inc., Seattle, WA, USA.
García-Verdugo JM; Bioinformatics and Data Mining, Global Research Technologies, Novo Nordisk A/S, Maaloev, Denmark.
Secher A; Obesity Research Unit, Novo Nordisk Research Center Seattle, Inc., Seattle, WA, USA.
Jorgensen R; UW Medicine Diabetes Institute, University of Washington, Seattle, WA, USA.
Schwartz MW; Department of Neuroscience, University of Copenhagen, Copenhagen, Denmark.
Pers TH; Cavanilles Institute of Biodiversity and Evolutionary Biology, University of Valencia, Valencia, Spain.

Nat Commun ; 11(1): 4458, 2020 09 07.

Article en En | MEDLINE | ID: mdl-32895383

Asunto(s)

Diabetes Mellitus Experimental/dietoterapia; Diabetes Mellitus Tipo 2/tratamiento farmacológico; Factor 1 de Crecimiento de Fibroblastos/administración & dosificación; Hipoglucemiantes/administración & dosificación; Hipotálamo/efectos de los fármacos; Proteínas Recombinantes/administración & dosificación; Proteína Relacionada con Agouti/metabolismo; Animales; Astrocitos/efectos de los fármacos; Astrocitos/metabolismo; Glucemia/análisis; Comunicación Celular; Núcleo Celular/efectos de los fármacos; Núcleo Celular/metabolismo; Diabetes Mellitus Experimental/sangre; Diabetes Mellitus Experimental/etiología; Diabetes Mellitus Experimental/patología; Diabetes Mellitus Tipo 2/sangre; Diabetes Mellitus Tipo 2/etiología; Diabetes Mellitus Tipo 2/patología; Dieta Alta en Grasa/efectos adversos; Sacarosa en la Dieta/administración & dosificación; Sacarosa en la Dieta/efectos adversos; Humanos; Hipotálamo/citología; Hipotálamo/patología; Inyecciones Intraventriculares; Leptina/genética; Masculino; Melanocortinas/metabolismo; Hormonas Estimuladoras de los Melanocitos/administración & dosificación; Ratones; Ratones Noqueados; Neuronas/efectos de los fármacos; Neuronas/metabolismo; Oligodendroglía/efectos de los fármacos; Oligodendroglía/metabolismo; RNA-Seq; Receptor de Melanocortina Tipo 4/genética; Receptores de Melanocortina/antagonistas & inhibidores; Receptores de Melanocortina/metabolismo; Inducción de Remisión/métodos; Transducción de Señal/efectos de los fármacos; Análisis de la Célula Individual; Técnicas Estereotáxicas; Transcriptoma/efectos de los fármacos

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Proteínas Recombinantes / Factor 1 de Crecimiento de Fibroblastos / Diabetes Mellitus Experimental / Diabetes Mellitus Tipo 2 / Hipoglucemiantes / Hipotálamo Tipo de estudio: Etiology_studies / Prognostic_studies Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos

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