Spatial evaluation of long-term metabolic changes induced by cisplatin nephrotoxicity.

Sahin, Mikail; Neumann, Judith M; Riefke, Bjoern; Bednarz, Hanna; Gutberlet, Katrin; Giampà, Marco; Niehaus, Karsten; Fatangare, Amol

Sahin, Mikail; Neumann, Judith M; Riefke, Bjoern; Bednarz, Hanna; Gutberlet, Katrin; Giampà, Marco; Niehaus, Karsten; Fatangare, Amol.

Afiliación

Sahin M; Proteome and Metabolome Research, Center for Biotechnology (CeBiTec), Faculty of Biology, Bielefeld University, Bielefeld, Germany.
Neumann JM; Proteome and Metabolome Research, Center for Biotechnology (CeBiTec), Faculty of Biology, Bielefeld University, Bielefeld, Germany.
Riefke B; Toxicology, Translational Science, Pharmaceuticals Division, Bayer AG, Berlin, Germany.
Bednarz H; Proteome and Metabolome Research, Center for Biotechnology (CeBiTec), Faculty of Biology, Bielefeld University, Bielefeld, Germany.
Gutberlet K; Toxicology, Translational Science, Pharmaceuticals Division, Bayer AG, Berlin, Germany.
Giampà M; Proteome and Metabolome Research, Center for Biotechnology (CeBiTec), Faculty of Biology, Bielefeld University, Bielefeld, Germany.
Niehaus K; Proteome and Metabolome Research, Center for Biotechnology (CeBiTec), Faculty of Biology, Bielefeld University, Bielefeld, Germany.
Fatangare A; Toxicology, Translational Science, Pharmaceuticals Division, Bayer AG, Berlin, Germany. Electronic address: amol.fatangare@isas.de.

Toxicol Lett ; 334: 36-43, 2020 Nov 01.

Article en En | MEDLINE | ID: mdl-32941993

Asunto(s)

Antineoplásicos/toxicidad; Antioxidantes/metabolismo; Cisplatino/toxicidad; Metabolismo Energético/efectos de los fármacos; Riñón/efectos de los fármacos; Animales; Biomarcadores/metabolismo; Inyecciones Intraperitoneales; Riñón/metabolismo; Riñón/patología; Túbulos Renales/efectos de los fármacos; Túbulos Renales/metabolismo; Túbulos Renales/patología; Masculino; Ratas Wistar; Factores de Tiempo

Palabras clave

Cisplatin; Long-term effects; MALDI; Mass Spectrometry Imaging (MSI); Metabolomics; Nephrotoxicity

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Cisplatino / Metabolismo Energético / Riñón / Antineoplásicos / Antioxidantes Límite: Animals Idioma: En Revista: Toxicol Lett Año: 2020 Tipo del documento: Article País de afiliación: Alemania

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