mTOR-mediated cancer drug resistance suppresses autophagy and generates a druggable metabolic vulnerability.

Gremke, Niklas; Polo, Pierfrancesco; Dort, Aaron; Schneikert, Jean; Elmshäuser, Sabrina; Brehm, Corinna; Klingmüller, Ursula; Schmitt, Anna; Reinhardt, Hans Christian; Timofeev, Oleg; Wanzel, Michael; Stiewe, Thorsten

Gremke, Niklas; Polo, Pierfrancesco; Dort, Aaron; Schneikert, Jean; Elmshäuser, Sabrina; Brehm, Corinna; Klingmüller, Ursula; Schmitt, Anna; Reinhardt, Hans Christian; Timofeev, Oleg; Wanzel, Michael; Stiewe, Thorsten.

Afiliación

Gremke N; Institute of Molecular Oncology, Philipps-University, Marburg, Germany.
Polo P; Institute of Molecular Oncology, Philipps-University, Marburg, Germany.
Dort A; Institute of Molecular Oncology, Philipps-University, Marburg, Germany.
Schneikert J; Institute of Molecular Oncology, Philipps-University, Marburg, Germany.
Elmshäuser S; Institute of Molecular Oncology, Philipps-University, Marburg, Germany.
Brehm C; Institute of Pathology, Philipps-University, Marburg, Germany.
Klingmüller U; Division Systems Biology of Signal Transduction, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Schmitt A; Translational Lung Research Center Heidelberg (TLRC), German Center for Lung Research (DZL), Heidelberg, Germany.
Reinhardt HC; Clinic for Hematology and Stem Cell Transplantation, West German Cancer Center, University Hospital Essen, German Cancer Consortium (DKTK), Essen, Germany.
Timofeev O; Clinic for Hematology and Stem Cell Transplantation, West German Cancer Center, University Hospital Essen, German Cancer Consortium (DKTK), Essen, Germany.
Wanzel M; Institute of Molecular Oncology, Philipps-University, Marburg, Germany.
Stiewe T; Institute of Molecular Oncology, Philipps-University, Marburg, Germany.

Nat Commun ; 11(1): 4684, 2020 09 17.

Article en En | MEDLINE | ID: mdl-32943635

Asunto(s)

Antineoplásicos/farmacología; Resistencia a Antineoplásicos/efectos de los fármacos; Serina-Treonina Quinasas TOR/metabolismo; Animales; Apoptosis/efectos de los fármacos; Autofagia/genética; Línea Celular Tumoral; Supervivencia Celular/efectos de los fármacos; Desoxiglucosa; Quimioterapia; Femenino; Humanos; Neoplasias Pulmonares; Masculino; Diana Mecanicista del Complejo 1 de la Rapamicina; Ratones; Transducción de Señal/efectos de los fármacos; Ensayos Antitumor por Modelo de Xenoinjerto

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Resistencia a Antineoplásicos / Serina-Treonina Quinasas TOR / Antineoplásicos Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans / Male Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2020 Tipo del documento: Article País de afiliación: Alemania

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