Your browser doesn't support javascript.
loading
Seroepidemiology of TORCH antibodies in the reproductive-aged women in China.
Qi, Ying; Zhu, Shu; Li, Chao; Wu, Hong; Yue, Huakui; Zhang, Yuncong; Zhu, Baosheng; Ma, Jian; Feng, Zhenru; Kong, Hui; Cai, Xushan; Ruan, Qiang.
Afiliación
  • Qi Y; Virology Laboratory, Shengjing Hospital of China Medical University, Shenyang, 110004, PR China.
  • Zhu S; Department of Medicial Genetics, First People's Hospital of Yunnan Province, Kunming, 650032, PR China.
  • Li C; Department of Clinical Laboratory, Chengdu Jinjiang Hospital for Women and Children Health, Chengdu, 610061, PR China.
  • Wu H; Department of Clinical Laboratory, Yantai Yuhuangding Hospital, Yantai, 264000, PR China.
  • Yue H; Department of Clinical Laboratory, Shenzhen People's Hospital, Shenzhen, 518001, PR China.
  • Zhang Y; Department of Clinical Laboratory, Peking University First Hospital, Beijing, 100034, PR China.
  • Zhu B; Department of Medicial Genetics, First People's Hospital of Yunnan Province, Kunming, 650032, PR China.
  • Ma J; Department of Clinical Laboratory, Chengdu Jinjiang Hospital for Women and Children Health, Chengdu, 610061, PR China.
  • Feng Z; Department of Clinical Laboratory, Peking University First Hospital, Beijing, 100034, PR China.
  • Kong H; Central Laboratory, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, 361003, PR China.
  • Cai X; Department of Clinical Laboratory, Shanghai Jiading Maternal and Child Health Hospital, Shanghai, 201899, PR China.
  • Ruan Q; Virology Laboratory, Shengjing Hospital of China Medical University, Shenyang, 110004, PR China. Electronic address: ruanq@sj-hospital.org.
Eur J Obstet Gynecol Reprod Biol ; 254: 114-118, 2020 Nov.
Article en En | MEDLINE | ID: mdl-32957008
TORCH, the acronym of Toxoplasma gondii (TOX), others, rubella virus (RUV), cytomegalovirus (CMV) and herpes simplex virus (HSV), is a major contributor to congenital infection. National population-based study on the seroepidemiology of TORCH in women is yet lacking, and it is still obscure whether TORCH infection in the women was associated with adverse pregnancy outcomes. A total of 48,406 asymptomatic women from eight hospitals in China which covered the most areas of mainland China were enrolled in this study, and 26,400 were simultaneously subjected to 7 detection tests for TORCH specific antibodies. Chemiluminescent immunoassay was performed to detect TORCH Immunoglobulin M (IgM) and/or Immunoglobulin G (IgG) antibodies, and IgG avidities of TOX and CMV IgM and IgG positive serum samples. The overall IgG prevalence of TOX, RUV, CMV and HSV-(1 + 2) in the reproductive-aged women was 1.71 %, 81.97 %, 95.09 % and 90.15 % respectively. The corresponding IgM prevalence of TOX, RUV and CMV was 0.30 %, 0.89 % and 0.52 %. Moreover, the rates of primary TOX and CMV infections were at least 0.08 % (21/26,400) and 0.03 % (7/26,400) in the studied population. The distributions of TORCH positive women in various age, season and region groups were different (P < 0.05). The CMV IgM-positive rate was higher in the pregnant women than those in non-pregnant women (P < 0.05). The higher past infection rates of RUV, CMV and HSV in women with bad obstetric history (BOH) imply that TORCH infections are associated with BOH. These data suggest that TORCH infections in the prenatal women, especially with BOH, are worthwhile to be screened by detections of specific IgG and IgM antibodies, and even IgG avidities.
Asunto(s)
Palabras clave

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Complicaciones Infecciosas del Embarazo / Rubéola (Sarampión Alemán) / Toxoplasmosis Tipo de estudio: Risk_factors_studies Límite: Adult / Female / Humans / Pregnancy País/Región como asunto: Asia Idioma: En Revista: Eur J Obstet Gynecol Reprod Biol Año: 2020 Tipo del documento: Article

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Complicaciones Infecciosas del Embarazo / Rubéola (Sarampión Alemán) / Toxoplasmosis Tipo de estudio: Risk_factors_studies Límite: Adult / Female / Humans / Pregnancy País/Región como asunto: Asia Idioma: En Revista: Eur J Obstet Gynecol Reprod Biol Año: 2020 Tipo del documento: Article