Multiple Mutations in Mycobacterium tuberculosis MmpL3 Increase Resistance to MmpL3 Inhibitors.

McNeil, Matthew B; O'Malley, Theresa; Dennison, Devon; Shelton, Catherine D; Sunde, Bjorn; Parish, Tanya

McNeil, Matthew B; O'Malley, Theresa; Dennison, Devon; Shelton, Catherine D; Sunde, Bjorn; Parish, Tanya.

Afiliación

McNeil MB; TB Discovery Research, Infectious Disease Research Institute, Seattle, Washington, USA.
O'Malley T; TB Discovery Research, Infectious Disease Research Institute, Seattle, Washington, USA.
Dennison D; TB Discovery Research, Infectious Disease Research Institute, Seattle, Washington, USA.
Shelton CD; TB Discovery Research, Infectious Disease Research Institute, Seattle, Washington, USA.
Sunde B; TB Discovery Research, Infectious Disease Research Institute, Seattle, Washington, USA.
Parish T; TB Discovery Research, Infectious Disease Research Institute, Seattle, Washington, USA tanya.parish@seattlechildrens.org.

mSphere ; 5(5)2020 10 14.

Article en En | MEDLINE | ID: mdl-33055263

Asunto(s)

Antibacterianos/farmacología; Proteínas Bacterianas/antagonistas & inhibidores; Proteínas Bacterianas/genética; Farmacorresistencia Bacteriana/genética; Proteínas de Transporte de Membrana/genética; Mycobacterium tuberculosis/efectos de los fármacos; Mycobacterium tuberculosis/genética; Transporte Biológico/efectos de los fármacos; Pared Celular/efectos de los fármacos; Humanos; Pruebas de Sensibilidad Microbiana; Mutación; Tuberculosis/microbiología

Palabras clave

antibiotic resistance; cell wall; drug discovery; mechanism of resistance; mode of action; mycobacteria; mycolic acids

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Proteínas de Transporte de Membrana / Proteínas Bacterianas / Farmacorresistencia Bacteriana / Antibacterianos / Mycobacterium tuberculosis Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: MSphere Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos

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