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Receptor-Driven ERK Pulses Reconfigure MAPK Signaling and Enable Persistence of Drug-Adapted BRAF-Mutant Melanoma Cells.
Gerosa, Luca; Chidley, Christopher; Fröhlich, Fabian; Sanchez, Gabriela; Lim, Sang Kyun; Muhlich, Jeremy; Chen, Jia-Yun; Vallabhaneni, Sreeram; Baker, Gregory J; Schapiro, Denis; Atanasova, Mariya I; Chylek, Lily A; Shi, Tujin; Yi, Lian; Nicora, Carrie D; Claas, Allison; Ng, Thomas S C; Kohler, Rainer H; Lauffenburger, Douglas A; Weissleder, Ralph; Miller, Miles A; Qian, Wei-Jun; Wiley, H Steven; Sorger, Peter K.
Afiliación
  • Gerosa L; Laboratory of Systems Pharmacology, Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.
  • Chidley C; Laboratory of Systems Pharmacology, Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.
  • Fröhlich F; Laboratory of Systems Pharmacology, Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.
  • Sanchez G; Laboratory of Systems Pharmacology, Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.
  • Lim SK; Laboratory of Systems Pharmacology, Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.
  • Muhlich J; Laboratory of Systems Pharmacology, Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.
  • Chen JY; Laboratory of Systems Pharmacology, Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.
  • Vallabhaneni S; Laboratory of Systems Pharmacology, Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.
  • Baker GJ; Laboratory of Systems Pharmacology, Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.
  • Schapiro D; Laboratory of Systems Pharmacology, Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Atanasova MI; Laboratory of Systems Pharmacology, Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.
  • Chylek LA; Laboratory of Systems Pharmacology, Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.
  • Shi T; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA.
  • Yi L; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA.
  • Nicora CD; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA.
  • Claas A; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
  • Ng TSC; Center for Systems Biology, Massachusetts General Hospital Research Institute, Boston, MA 02114, USA.
  • Kohler RH; Center for Systems Biology, Massachusetts General Hospital Research Institute, Boston, MA 02114, USA.
  • Lauffenburger DA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
  • Weissleder R; Center for Systems Biology, Massachusetts General Hospital Research Institute, Boston, MA 02114, USA.
  • Miller MA; Center for Systems Biology, Massachusetts General Hospital Research Institute, Boston, MA 02114, USA.
  • Qian WJ; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA.
  • Wiley HS; Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, WA 99354, USA.
  • Sorger PK; Laboratory of Systems Pharmacology, Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: peter_sorger@hms.harvard.edu.
Cell Syst ; 11(5): 478-494.e9, 2020 11 18.
Article en En | MEDLINE | ID: mdl-33113355
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Sistema de Señalización de MAP Quinasas / Proteínas Proto-Oncogénicas B-raf / Melanoma Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Cell Syst Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Sistema de Señalización de MAP Quinasas / Proteínas Proto-Oncogénicas B-raf / Melanoma Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Cell Syst Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos