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Electrical stimulation of the endopiriform nucleus attenuates epilepsy in rats by network modulation.
Li, Donghong; Luo, Deng; Wang, Junling; Wang, Wei; Yuan, Zhangyi; Xing, Yue; Yan, Jiaqing; Sha, Zhiyi; Loh, Horace H; Zhang, Milin; Henry, Thomas R; Yang, Xiaofeng.
Afiliación
  • Li D; Beijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, China.
  • Luo D; Neuroelectrophysiological Laboratory, Xuanwu Hospital, Capital Medical University, Beijing, China.
  • Wang J; Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou, China.
  • Wang W; Department of Electronic Engineering, Institute of Microelectronics, Tsinghua University, Beijing, China.
  • Yuan Z; Beijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, China.
  • Xing Y; Neuroelectrophysiological Laboratory, Xuanwu Hospital, Capital Medical University, Beijing, China.
  • Yan J; Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou, China.
  • Sha Z; Beijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, China.
  • Loh HH; Neuroelectrophysiological Laboratory, Xuanwu Hospital, Capital Medical University, Beijing, China.
  • Zhang M; Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou, China.
  • Henry TR; Department of Electronic Engineering, Institute of Microelectronics, Tsinghua University, Beijing, China.
  • Yang X; Neuroelectrophysiological Laboratory, Xuanwu Hospital, Capital Medical University, Beijing, China.
Ann Clin Transl Neurol ; 7(12): 2356-2369, 2020 12.
Article en En | MEDLINE | ID: mdl-33128504
ABSTRACT

OBJECTIVE:

Neuromodulatory anterior thalamic deep brain stimulation (DBS) is an effective therapy for intractable epilepsy, but few patients achieve complete seizure control with thalamic DBS. Other stimulation sites may be considered for anti-seizure DBS. We investigated bilateral low-frequency stimulation of the endopiriform nuclei (LFS-EPN) to control seizures induced by intracortically implanted cobalt wire in rats.

METHODS:

Chronic epilepsy was induced by cobalt wire implantation in the motor cortex unilaterally. Bipolar-stimulating electrodes were implanted into the EPN bilaterally. Continuous electroencephalography (EEG) was recorded using electrodes placed into bilateral motor cortex and hippocampus CA1 areas. Spontaneous seizures were monitored by long-term video-EEG, and behavioral seizures were classified based on the Racine scale. Continuous 1-Hz LFS-EPN began on the third day after electrode implantation and was controlled by a multi-channel stimulator. Stimulation continued until the rats had no seizures for three consecutive days.

RESULTS:

Compared with the control and sham stimulation groups, the LFS-EPN group experienced significantly fewer seizures per day and the mean Racine score of seizures was lower due to fewer generalized seizures. Ictal discharges at the epileptogenic site had significantly reduced theta band power in the LFS-EPN group compared to the other groups.

INTERPRETATION:

Bilateral LFS-EPN attenuates cobalt wire-induced seizures in rats by modulating epileptic networks. Reduced ictal theta power of the EEG broadband spectrum at the lesion site may be associated with the anti-epileptogenic mechanism of LFS-EPN. Bilateral EPN DBS may have therapeutic applications in human partial epilepsies.
Asunto(s)

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Ritmo Teta / Terapia por Estimulación Eléctrica / Epilepsia / Corteza Piriforme / Corteza Motora Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Ann Clin Transl Neurol Año: 2020 Tipo del documento: Article País de afiliación: China

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Ritmo Teta / Terapia por Estimulación Eléctrica / Epilepsia / Corteza Piriforme / Corteza Motora Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Ann Clin Transl Neurol Año: 2020 Tipo del documento: Article País de afiliación: China