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Akt3 induces oxidative stress and DNA damage by activating the NADPH oxidase via phosphorylation of p47phox.
Polytarchou, Christos; Hatziapostolou, Maria; Yau, Tung On; Christodoulou, Niki; Hinds, Philip W; Kottakis, Filippos; Sanidas, Ioannis; Tsichlis, Philip N.
Afiliación
  • Polytarchou C; Department of Cancer Biology and Genetics, The Ohio State University Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210; christos.polytarchou@ntu.ac.uk Philip.Tsichlis@osumc.edu.
  • Hatziapostolou M; Department of Biosciences, John van Geest Cancer Research Centre, School of Science and Technology, Nottingham Trent University, NG11 8NS Nottingham, United Kingdom.
  • Yau TO; Centre for Health, Aging and Understanding Disease, Nottingham Trent University, NG11 8NS Nottingham, United Kingdom.
  • Christodoulou N; Molecular Oncology Research Institute, Tufts Medical Center, Boston, MA 02111.
  • Hinds PW; Department of Biosciences, John van Geest Cancer Research Centre, School of Science and Technology, Nottingham Trent University, NG11 8NS Nottingham, United Kingdom.
  • Kottakis F; Centre for Health, Aging and Understanding Disease, Nottingham Trent University, NG11 8NS Nottingham, United Kingdom.
  • Sanidas I; Molecular Oncology Research Institute, Tufts Medical Center, Boston, MA 02111.
  • Tsichlis PN; Department of Biosciences, John van Geest Cancer Research Centre, School of Science and Technology, Nottingham Trent University, NG11 8NS Nottingham, United Kingdom.
Proc Natl Acad Sci U S A ; 117(46): 28806-28815, 2020 11 17.
Article en En | MEDLINE | ID: mdl-33139577
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Daño del ADN / Estrés Oxidativo / NADPH Oxidasas / Proteínas Proto-Oncogénicas c-akt Límite: Animals Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2020 Tipo del documento: Article
Texto completo
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Daño del ADN / Estrés Oxidativo / NADPH Oxidasas / Proteínas Proto-Oncogénicas c-akt Límite: Animals Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2020 Tipo del documento: Article