Programmed death ligand 1 protein expression is positively correlated with the solid predominant subtype, high MIB-1 labeling index, and p53 expression and negatively correlated with epidermal growth factor receptor mutations in lung adenocarcinoma.

Yanagawa, Naoki; Shiono, Satoshi; Endo, Makoto; Ogata, Shin-Ya; Yamada, Noriyuki; Sugimoto, Ryo; Osakabe, Mitsumasa; Uesugi, Noriyuki; Sugai, Tamotsu

Yanagawa, Naoki; Shiono, Satoshi; Endo, Makoto; Ogata, Shin-Ya; Yamada, Noriyuki; Sugimoto, Ryo; Osakabe, Mitsumasa; Uesugi, Noriyuki; Sugai, Tamotsu.

Afiliación

Yanagawa N; Department of Molecular Diagnostic Pathology, Iwate Medical University, Shiwa-gun, Iwate, 0283695, Japan. Electronic address: nyanagaw@iwate-med.ac.jp.
Shiono S; Departments of Thoracic Surgery and Yamagata Prefectural Central Hospital, Yamagata, Yamagata, 9902292, Japan.
Endo M; Departments of Thoracic Surgery and Yamagata Prefectural Central Hospital, Yamagata, Yamagata, 9902292, Japan.
Ogata SY; Diagnostic Pathology, Yamagata Prefectural Central Hospital, Yamagata, Yamagata, 9902292, Japan.
Yamada N; Department of Molecular Diagnostic Pathology, Iwate Medical University, Shiwa-gun, Iwate, 0283695, Japan.
Sugimoto R; Department of Molecular Diagnostic Pathology, Iwate Medical University, Shiwa-gun, Iwate, 0283695, Japan.
Osakabe M; Department of Molecular Diagnostic Pathology, Iwate Medical University, Shiwa-gun, Iwate, 0283695, Japan.
Uesugi N; Department of Molecular Diagnostic Pathology, Iwate Medical University, Shiwa-gun, Iwate, 0283695, Japan.
Sugai T; Department of Molecular Diagnostic Pathology, Iwate Medical University, Shiwa-gun, Iwate, 0283695, Japan.

Hum Pathol ; 108: 12-21, 2021 02.

Article en En | MEDLINE | ID: mdl-33159965

Asunto(s)

Adenocarcinoma del Pulmón/patología; Antígeno B7-H1/biosíntesis; Biomarcadores de Tumor/análisis; Neoplasias Pulmonares/patología; Adenocarcinoma del Pulmón/genética; Adenocarcinoma del Pulmón/metabolismo; Adulto; Anciano; Anciano de 80 o más Años; Carcinoma de Células Escamosas/genética; Carcinoma de Células Escamosas/metabolismo; Carcinoma de Células Escamosas/patología; Receptores ErbB/genética; Femenino; Humanos; Antígeno Ki-67/metabolismo; Neoplasias Pulmonares/genética; Neoplasias Pulmonares/metabolismo; Masculino; Persona de Mediana Edad; Mutación; Estudios Retrospectivos; Proteína p53 Supresora de Tumor/biosíntesis

Palabras clave

EGFR; Lung adenocarcinoma; MIB-1; PD-L1; Solid predominant subtype; Tissue microarray; p53

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Biomarcadores de Tumor / Antígeno B7-H1 / Adenocarcinoma del Pulmón / Neoplasias Pulmonares Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Hum Pathol Asunto de la revista: PATOLOGIA Año: 2021 Tipo del documento: Article

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