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RIPK1 Expression Associates With Inflammation in Early Atherosclerosis in Humans and Can Be Therapeutically Silenced to Reduce NF-κB Activation and Atherogenesis in Mice.
Karunakaran, Denuja; Nguyen, My-Anh; Geoffrion, Michele; Vreeken, Dianne; Lister, Zachary; Cheng, Henry S; Otte, Nicola; Essebier, Patricia; Wyatt, Hailey; Kandiah, Joshua W; Jung, Richard; Alenghat, Francis J; Mompeon, Ana; Lee, Richard; Pan, Calvin; Gordon, Emma; Rasheed, Adil; Lusis, Aldons J; Liu, Peter; Matic, Ljubica Perisic; Hedin, Ulf; Fish, Jason E; Guo, Liang; Kolodgie, Frank; Virmani, Renu; van Gils, Janine M; Rayner, Katey J.
Afiliación
  • Karunakaran D; University of Ottawa Heart Institute, Canada (D.K., M.-A.N., M.G., Z.L., H.W., J.W.K., R.J., A.M., A.R., P.L., K.J.R.).
  • Nguyen MA; Institute for Molecular Bioscience, University of Queensland, St Lucia, Australia (D.K., N.O., P.E., E.G.).
  • Geoffrion M; University of Ottawa Heart Institute, Canada (D.K., M.-A.N., M.G., Z.L., H.W., J.W.K., R.J., A.M., A.R., P.L., K.J.R.).
  • Vreeken D; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ontario, Canada (M.-A.N., K.J.R.).
  • Lister Z; University of Ottawa Heart Institute, Canada (D.K., M.-A.N., M.G., Z.L., H.W., J.W.K., R.J., A.M., A.R., P.L., K.J.R.).
  • Cheng HS; Leiden University Medical Center, The Netherlands (D.V., J.M.v.G.).
  • Otte N; University of Ottawa Heart Institute, Canada (D.K., M.-A.N., M.G., Z.L., H.W., J.W.K., R.J., A.M., A.R., P.L., K.J.R.).
  • Essebier P; Toronto General Research Hospital Institute, University Health Network, Department of Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada (H.S.C.).
  • Wyatt H; Institute for Molecular Bioscience, University of Queensland, St Lucia, Australia (D.K., N.O., P.E., E.G.).
  • Kandiah JW; Institute for Molecular Bioscience, University of Queensland, St Lucia, Australia (D.K., N.O., P.E., E.G.).
  • Jung R; University of Ottawa Heart Institute, Canada (D.K., M.-A.N., M.G., Z.L., H.W., J.W.K., R.J., A.M., A.R., P.L., K.J.R.).
  • Alenghat FJ; University of Ottawa Heart Institute, Canada (D.K., M.-A.N., M.G., Z.L., H.W., J.W.K., R.J., A.M., A.R., P.L., K.J.R.).
  • Mompeon A; University of Ottawa Heart Institute, Canada (D.K., M.-A.N., M.G., Z.L., H.W., J.W.K., R.J., A.M., A.R., P.L., K.J.R.).
  • Lee R; Cardiology, Department of Medicine, University of Chicago, IL (F.J.A., J.E.F.).
  • Pan C; University of Ottawa Heart Institute, Canada (D.K., M.-A.N., M.G., Z.L., H.W., J.W.K., R.J., A.M., A.R., P.L., K.J.R.).
  • Gordon E; Cardiovascular Antisense Drug Discovery Group, Ionis Pharmaceuticals, Carlsbad, CA (R.L.).
  • Rasheed A; David Geffen School of Medicine, University of California Los Angeles (C.P., A.J.L.).
  • Lusis AJ; Institute for Molecular Bioscience, University of Queensland, St Lucia, Australia (D.K., N.O., P.E., E.G.).
  • Liu P; University of Ottawa Heart Institute, Canada (D.K., M.-A.N., M.G., Z.L., H.W., J.W.K., R.J., A.M., A.R., P.L., K.J.R.).
  • Matic LP; David Geffen School of Medicine, University of California Los Angeles (C.P., A.J.L.).
  • Hedin U; University of Ottawa Heart Institute, Canada (D.K., M.-A.N., M.G., Z.L., H.W., J.W.K., R.J., A.M., A.R., P.L., K.J.R.).
  • Fish JE; Vascular Surgery Division, Department of Molecular Medicine and Surgery, Karolinska Institute, Sweden (L.P.M.).
  • Kolodgie F; Cardiology, Department of Medicine, University of Chicago, IL (F.J.A., J.E.F.).
  • Virmani R; CVPath Institute Inc., Gaithersburg, MD (L.G., F.K., R.V.).
  • van Gils JM; CVPath Institute Inc., Gaithersburg, MD (L.G., F.K., R.V.).
  • Rayner KJ; CVPath Institute Inc., Gaithersburg, MD (L.G., F.K., R.V.).
Circulation ; 143(2): 163-177, 2021 01 12.
Article en En | MEDLINE | ID: mdl-33222501
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: FN-kappa B / Mediadores de Inflamación / Silenciador del Gen / Aterosclerosis / Proteína Serina-Treonina Quinasas de Interacción con Receptores Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals / Female / Humans / Male Idioma: En Revista: Circulation Año: 2021 Tipo del documento: Article
Texto completo
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: FN-kappa B / Mediadores de Inflamación / Silenciador del Gen / Aterosclerosis / Proteína Serina-Treonina Quinasas de Interacción con Receptores Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals / Female / Humans / Male Idioma: En Revista: Circulation Año: 2021 Tipo del documento: Article