ADAMTS1, a disintegrin-like and metalloproteinase with thrombospondin type 1; ALP, alkaline phosphatase; BALP (BSAP), bone-specific alkaline phosphatase; BC, breast cancer; BM, bone metastases; BOLCs, breast osteoblast-like cells; BTM, bone turnover markers; Biomarkers; Bone metastases; Breast cancer; CAPG, capping-protein; CCN3, cellular communication network factor 3; CDH11, cadherin-11; CNV, copy number variation; CTGF, connective tissue-derived growth factor; CTSK, cathepsin K; CTX, C-telopeptide; CXCL, C-X-C-ligand; CXCR, C­X­C motif chemokine receptor; DEGs, differentially expressed genes; DOCK4, dedicator of cytokinesis protein 4; DPD, deoxypyridoline; DTC, disseminated tumour cells; EMT, epithelial-to-mesenchymal transition; ER, estrogen receptor; ERRα, estrogen-related receptor alpha; FAK, focal adhesion kinase; FGF, fibroblast growth factor; FST, follistatin; GIPC1, PDZ domain-containing protein member 1; HR, hazard ratio; Her, human epidermal growth factor; ICAM-1, intercellular adhesion molecule 1; IGF, insulin-like growth factor; IHC, immunohistochemistry; IL, interleukin; LC/MS/MS, liquid chromatography/mass spectrometry/mass spectrometry; MAF, v-maf avian muscolo aponeurotic fibro-sarcoma oncogene homolog; MDA-MB, MD Anderson metastatic BC; MMP1, matrix metalloproteinase-1; NTX, N-telopeptide; OPG, osteoprotegerin; Omics sciences; Osteotropism; P1CP, pro-collagen type I C-terminal; P1NP, pro-collagen type I N-terminal; PDGF, platelet-derived growth factor; PRG1, proteoglycan-1; PTH-rP, parathyroid hormone-related protein; PYD, pyridoline; PgR, progesterone receptor; PlGF, placental growth factor; RANK, receptor activator of nuclear factor к-B; RT-PCR, real time-PCR; SILAC-MS, stable isotope labelling by amino acids in cell culture-mass spectrometry; SNPs, single nucleotide polymorphisms; SPP1, osteopontin; SREs, skeletal-related events; TCGA, the cancer genome atlas; TGF-ß, transforming growth factor beta; TNF-α, tumor necrosis factor-α; TRACP-5b, tartrate resistant acid phosphatase-5b; VEGF, vascular endothelial growth factor; ZNF217, zinc-finger protein 217; miRNAs, microRNAs; ncRNAs, noncoding RNA