Echocardiographic signs of subclinical cardiac function impairment in Duchenne dystrophy gene carriers.
Sci Rep
; 10(1): 20794, 2020 11 27.
Article
en En
| MEDLINE
| ID: mdl-33247228
ABSTRACT
To assess subclinical cardiac function impairment in Duchenne dystrophy (DMD) female carriers. Forty-four female subjects proved as DMD carriers underwent echocardiographic examination including tissue Doppler imaging (TDI) of mitral and tricuspid annulus. Seventeen age-matched healthy female subjects served as controls. A significant differences in peak systolic annular velocity (Sa) between carriers and controls were found for lateral and septal part of the mitral annulus and for tricuspid annulus (0.09 vs. 0.11 m/s, p < 0.001, 0.08 vs. 0.09 m/s, p < 0.01 and 0.13 vs. 0.14 m/s, p = 0.02 respectively). There was also difference in early diastolic velocity (Ea) of the septal part of the mitral annulus (0.11 vs. 0.13 m/s, p = 0.03). The subclinical deterioration of systolic function is presented even in asymptomatic DMD female carriers.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Distrofia Muscular de Duchenne
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Heterocigoto
Tipo de estudio:
Diagnostic_studies
/
Observational_studies
Límite:
Adult
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Female
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Humans
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Middle aged
Idioma:
En
Revista:
Sci Rep
Año:
2020
Tipo del documento:
Article
País de afiliación:
República Checa