Myocardial oxygen consumption during histidine-tryptophan-ketoglutarate cardioplegia in young human hearts.
Interact Cardiovasc Thorac Surg
; 32(2): 319-324, 2021 01 22.
Article
en En
| MEDLINE
| ID: mdl-33398332
ABSTRACT
OBJECTIVES:
Energy demand and supply need to be balanced to preserve myocardial function during paediatric cardiac surgery. After a latent aerobic period, cardiac cells try to maintain energy production by anaerobic metabolism and by extracting oxygen from the given cardioplegic solution. Myocardial oxygen consumption (MVO2) changes gradually during the administration of cardioplegia.METHODS:
MVO2 was measured during cardioplegic perfusion in patients younger than 6 months of age (group N neonates; group I infants), with a body weight less than 10 kg. Histidine-tryptophan-ketoglutarate crystalloid solution was used for myocardial protection and was administered during a 5-min interval. To measure pO2 values during cardioplegic arrest, a sample of the cardioplegic fluid was taken from the inflow line before infusion. Three fluid samples were taken from the coronary venous effluent 1, 3 and 5 min after the onset of cardioplegia administration. MVO2 was calculated using the Fick principle.RESULTS:
The mean age of group N was 0.2 ± 0.09 versus 4.5 ± 1.1 months in group I. The mean weight was 3.1 ± 0.2 versus 5.7 ± 1.6 kg, respectively. MVO2 decreased similarly in both groups (min 1 0.16 ± 0.07 vs 0.36 ± 0.1 ml/min; min 3 0.08 ± 0.04 vs 0.17 ± 0.09 ml/min; min 5 0.05 ± 0.04 vs 0.07 ± 0.05 ml/min).CONCLUSIONS:
We studied MVO2 alterations after aortic cross-clamping and during delivery of cardioplegia in neonates and infants undergoing cardiac surgery. Extended cardioplegic perfusion significantly reduces energy turnover in hearts because the balance procedures are both volume- and above all time-dependent. A reduction in MVO2 indicates the necessity of a prolonged cardioplegic perfusion time to achieve optimized myocardial protection.Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Consumo de Oxígeno
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Triptófano
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Soluciones Cardiopléjicas
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Corazón
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Histidina
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Ácidos Cetoglutáricos
Límite:
Animals
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Humans
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Male
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Newborn
Idioma:
En
Revista:
Interact Cardiovasc Thorac Surg
Asunto de la revista:
ANGIOLOGIA
/
CARDIOLOGIA
Año:
2021
Tipo del documento:
Article
País de afiliación:
Italia