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Cardiotoxicity induced by Cochinchina momordica seed extract in zebrafish.
Du, Zheng-Cai; Xia, Zhong-Shang; Huang, Yan-Feng; Peng, Yi; Cao, Bing-Bing; Li, Chun-Qi; Liang, Yun-Fei; Zhao, Fang-Hui; Zhang, Ming-Zhe; Chen, Zhang-Mei; Hou, Xiao-Tao; Hao, Er-Wei; Deng, Jia-Gang.
Afiliación
  • Du ZC; Guangxi Scientific Experimental Center of Traditional Chinese Medicine, Guangxi University of Traditional Chinese Medicine, Nanning, China.
  • Xia ZS; College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
  • Huang YF; Guangxi Key Laboratory of Efficacy Study on Chinese Materia Medica, Guangxi University of Traditional Chinese Medicine, Nanning, China.
  • Peng Y; Hunter Biotechnology, Inc., Transfarland, Hangzhou, China.
  • Cao BB; Hunter Biotechnology, Inc., Transfarland, Hangzhou, China.
  • Li CQ; Hunter Biotechnology, Inc., Transfarland, Hangzhou, China.
  • Liang YF; Hunter Biotechnology, Inc., Transfarland, Hangzhou, China.
  • Zhao FH; Guangxi Wuzhou Pharmaceutical Group Co., Ltd., Wuzhou, China.
  • Zhang MZ; Guangxi Key Laboratory of Efficacy Study on Chinese Materia Medica, Guangxi University of Traditional Chinese Medicine, Nanning, China.
  • Chen ZM; Guangxi Scientific Experimental Center of Traditional Chinese Medicine, Guangxi University of Traditional Chinese Medicine, Nanning, China.
  • Hou XT; Guangxi Scientific Experimental Center of Traditional Chinese Medicine, Guangxi University of Traditional Chinese Medicine, Nanning, China.
  • Hao EW; Guangxi Key Laboratory of Efficacy Study on Chinese Materia Medica, Guangxi University of Traditional Chinese Medicine, Nanning, China.
  • Deng JG; Guangxi Key Laboratory of Efficacy Study on Chinese Materia Medica, Guangxi University of Traditional Chinese Medicine, Nanning, China.
J Appl Toxicol ; 41(8): 1222-1231, 2021 08.
Article en En | MEDLINE | ID: mdl-33445225
Momordica cochinchinensis (Lour.) Spreng is an indigenous South Asian edible fruit, and seeds of Momordica cochinchinensis have been used therapeutically in traditional Chinese medicine. Previous studies have shown that M. cochinchinensis seed (Momordicae Semen) has various pharmaceutical properties such as antioxidant and anti-ulcer effects as well as contains secondary metabolites with potential anticancer activities such as triterpenoids and saponins. Recent studies reported that water extract and ethanol extract of M. cochinchinensi seed were tested on mammals using an acute toxic classic method as OECD guidelines 420. No matter injected intravenously or intramuscularly, animals died within several days. In this study, zebrafish embryos were exposed to various doses of Cochinchina momordica seed extract (CMSE) from 2 dpf (days post fertilization, dpf) to 3 dpf. CMSE-induced cardiotoxicity such as pericardial edema, cardiac apoptosis, increased ROS production, cardiac neutrophil infiltration, decreased blood flow velocity, and reduced expression of three marker genes of cardiac functions were found in zebrafish roughly in a dose-dependent manner. These results suggest that CMSE may induce cardiotoxicity through pathways involved in inflammation, oxidative stress, and apoptosis.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Semillas / Extractos Vegetales / Momordica / Cardiotoxicidad Tipo de estudio: Guideline Límite: Animals Idioma: En Revista: J Appl Toxicol Año: 2021 Tipo del documento: Article País de afiliación: China

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Semillas / Extractos Vegetales / Momordica / Cardiotoxicidad Tipo de estudio: Guideline Límite: Animals Idioma: En Revista: J Appl Toxicol Año: 2021 Tipo del documento: Article País de afiliación: China