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ALSUntangled 59: Tamoxifen.
Bedlack, Richard; Kihuwa-Mani, Sky; Barkhaus, Paul E; Bereman, Michael; Caress, James B; Crayle, Jesse; Pattee, Gary L; Heiman Patterson, Terry; Wicks, Paul; Zach, Neta; Carter, Gregory T; Salmon, Kristiana.
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  • Bedlack R; Department of Neurology, Duke University, Durham, NC, USA.
  • Kihuwa-Mani S; Lloyd International Honors College, University of North Carolina at Greensboro, Greensboro, NC, USA.
  • Barkhaus PE; Department of Neurology, Medical College of Wisconsin, Milwaukee, WI, USA.
  • Bereman M; Department of Biological Sciences, North Carolina State University, Raleigh, NC, USA.
  • Caress JB; Department of Neurology, Wake Forest Baptist Health, Winston-Salem, NC, USA.
  • Crayle J; Department of Neurology, Duke University, Durham, NC, USA.
  • Pattee GL; Department of Neurology, University of Nebraska Medical Center, Omaha, NB, USA.
  • Heiman Patterson T; Department of Neurology, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.
  • Wicks P; Independent consultant, United Kingdom of Great Britain and Northern Ireland.
  • Zach N; Department of Neuroscience, Takeda Pharmaceuticals USA Inc, Deerfield, IL, USA.
  • Carter GT; Department of Neurology, Saint Luke's-Elks Rehab, Boise, ID, USA.
  • Salmon K; Department of Neurology, McGill University Health Centre, Montreal, Canada.
Amyotroph Lateral Scler Frontotemporal Degener ; 22(7-8): 595-598, 2021 11.
Article en En | MEDLINE | ID: mdl-33474997
Here we use the ALSUntangled methodology to review Tamoxifen as an ALS treatment. We show that it has plausible mechanisms, a positive preclinical study, a case report and 2 small trials suggesting benefits. We show that it appears reasonably safe, though there is a small risk of developing cancer with long term use. While we cannot yet endorse this as an ALS treatment, there is enough evidence to warrant another larger ALS trial.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Tamoxifeno / Esclerosis Amiotrófica Lateral Límite: Humans Idioma: En Revista: Amyotroph Lateral Scler Frontotemporal Degener Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Tamoxifeno / Esclerosis Amiotrófica Lateral Límite: Humans Idioma: En Revista: Amyotroph Lateral Scler Frontotemporal Degener Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos