Proteomic Architecture of Valvular Extracellular Matrix: FNDC1 and MXRA5 Are New Biomarkers of Aortic Stenosis.

Bouchareb, Rihab; Guauque-Olarte, Sandra; Snider, Justin; Zaminski, Devyn; Anyanwu, Anelechi; Stelzer, Paul; Lebeche, Djamel

Bouchareb, Rihab; Guauque-Olarte, Sandra; Snider, Justin; Zaminski, Devyn; Anyanwu, Anelechi; Stelzer, Paul; Lebeche, Djamel.

Afiliación

Bouchareb R; Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Guauque-Olarte S; GIOD Group, Faculty of Dentistry, Universidad Cooperativa de Colombia, Pasto, Colombia.
Snider J; Biological Mass Spectrometry Shared Resource, Stony Brook University Cancer Center, New York, New York, USA.
Zaminski D; Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Anyanwu A; Department of Cardiovascular Surgery, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Stelzer P; Department of Cardiovascular Surgery, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Lebeche D; Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

JACC Basic Transl Sci ; 6(1): 25-39, 2021 Jan.

Article en En | MEDLINE | ID: mdl-33532664

Palabras clave

AS, aortic stenosis; EC, endothelial cell; ECM; ECM, extracellular matrix; FN, fibronectin; FNDC1, fibronectin type III domain containing 1; KEGG, Kyoto Encyclopedia of Genes and Genomes; LDL, low-density lipoprotein; MXRA5, matrix-remodeling-associated protein 5; MetS, metabolic syndrome; PBS, phosphate-buffered saline; RNA-Seq; RNAseq, RNA sequencing; TAVc, calcified tricuspid aortic valve; TAVn, noncalcified tricuspid aortic valve; VAHC, calcified human aortic valve; VAHN, normal human aortic valve; aortic stenosis; calcified aortic valves; hVIC, human valve interstitial cell; metabolism; proteomics

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Texto completo: 1 Base de datos: MEDLINE Idioma: En Revista: JACC Basic Transl Sci Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos

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PubMed Links

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Texto completo: 1 Base de datos: MEDLINE Idioma: En Revista: JACC Basic Transl Sci Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos