Novel Case Report: A Previously Reported, but Pathophysiologically Unexplained, Association Between Collagenous Colitis and Protein-Losing Enteropathy May Be Explained by an Undetected Link with Collagenous Duodenitis.
Dig Dis Sci
; 66(12): 4557-4564, 2021 12.
Article
en En
| MEDLINE
| ID: mdl-33537921
ABSTRACT
Collagenous colitis (CC) is associated with non-bloody, watery diarrhea, which is pathophysiologically reasonable because normal colonic absorption (or excretion) of water and electrolytes can be blocked by the abnormally thick collagen layer in CC. However, CC has also been associated with six previous cases of protein-losing enteropathy (PLE), with no pathophysiologic explanation. The colon does not normally absorb (or excrete) amino acids/proteins, which is primarily the function of the small bowel. Collagenous duodenitis (CD) has not been associated with PLE. This work reports a novel case of CD (and CC) associated with PLE; a pathophysiologically reasonable mechanism for CD causing PLE (by the thick collagen layer of CD blocking normal intestinal amino acid absorption); and a novel association of PLE with severe COVID-19 infection (attributed to relative immunosuppression from hypoproteinemia, hypoalbuminemia, hypogammaglobulinemia, and malnutrition from PLE).
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Enteropatías Perdedoras de Proteínas
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Colitis Colagenosa
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Duodenitis
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Duodeno
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COVID-19
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Aminoácidos
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Absorción Intestinal
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Mucosa Intestinal
Tipo de estudio:
Diagnostic_studies
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Etiology_studies
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Risk_factors_studies
Límite:
Aged
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Female
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Humans
Idioma:
En
Revista:
Dig Dis Sci
Año:
2021
Tipo del documento:
Article
País de afiliación:
Estados Unidos