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A semi-mechanistic exposure-response model to assess the effects of verinurad, a potent URAT1 inhibitor, on serum and urine uric acid in patients with hyperuricemia-associated diseases.
Leander, Jacob; Sunnåker, Mikael; Rekic, Dinko; Aksenov, Sergey; Eriksson, Ulf G; Johansson, Susanne; Parkinson, Joanna.
Afiliación
  • Leander J; Clinical Pharmacology and Quantitative Pharmacology, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Gothenburg, Sweden.
  • Sunnåker M; Clinical Pharmacology and Quantitative Pharmacology, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Gothenburg, Sweden.
  • Rekic D; Clinical Pharmacology and Quantitative Pharmacology, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Gothenburg, Sweden.
  • Aksenov S; Clinical Pharmacology and Quantitative Pharmacology, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Waltham, MA, USA.
  • Eriksson UG; Clinical Pharmacology and Quantitative Pharmacology, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Gothenburg, Sweden.
  • Johansson S; Clinical Pharmacology and Quantitative Pharmacology, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Gothenburg, Sweden.
  • Parkinson J; Clinical Pharmacology and Quantitative Pharmacology, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Gothenburg, Sweden. Joanna.parkinson@astrazeneca.com.
J Pharmacokinet Pharmacodyn ; 48(4): 525-541, 2021 08.
Article en En | MEDLINE | ID: mdl-33728547
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Propionatos / Piridinas / Ácido Úrico / Transportadores de Anión Orgánico / Proteínas de Transporte de Catión Orgánico / Hiperuricemia / Naftalenos Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: J Pharmacokinet Pharmacodyn Asunto de la revista: FARMACOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Suecia
Texto completo
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Propionatos / Piridinas / Ácido Úrico / Transportadores de Anión Orgánico / Proteínas de Transporte de Catión Orgánico / Hiperuricemia / Naftalenos Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: J Pharmacokinet Pharmacodyn Asunto de la revista: FARMACOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Suecia