Biocatalytic Approach for Direct Esterification of Ibuprofen with Sorbitol in Biphasic Media.
Int J Mol Sci
; 22(6)2021 Mar 17.
Article
en En
| MEDLINE
| ID: mdl-33802769
ABSTRACT
Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) introduced in the 1960s and widely used as an analgesic, anti-inflammatory, and antipyretic. In its acid form, the solubility of 21 mg/L greatly limits its bioavailability. Since the bioavailability of a drug product plays a critical role in the design of oral administration dosage, this study investigated the enzymatic esterification of ibuprofen as a strategy for hydrophilization. This work proposes an enzymatic strategy for the covalent attack of highly hydrophilic molecules using acidic functions of commercially available bioactive compounds. The poorly water-soluble drug ibuprofen was esterified in a hexane/water biphasic system by direct esterification with sorbitol using the cheap biocatalyst porcine pancreas lipase (PPL), which demonstrated itself to be a suitable enzyme for the effective production of the IBU-sorbitol ester. This work reports the optimization of the esterification reaction.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Sorbitol
/
Ibuprofeno
/
Medios de Cultivo
/
Biocatálisis
Límite:
Animals
Idioma:
En
Revista:
Int J Mol Sci
Año:
2021
Tipo del documento:
Article
País de afiliación:
Italia