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Anti-Inflammatory (M2) Response Is Induced by a sp2-Iminosugar Glycolipid Sulfoxide in Diabetic Retinopathy.
Cano-Cano, Fátima; Alcalde-Estévez, Elena; Gómez-Jaramillo, Laura; Iturregui, Marta; Sánchez-Fernández, Elena M; García Fernández, José M; Ortiz Mellet, Carmen; Campos-Caro, Antonio; López-Tinoco, Cristina; Aguilar-Diosdado, Manuel; Valverde, Ángela M; Arroba, Ana I.
Afiliación
  • Cano-Cano F; Research Unit, Instituto de Investigación e Innovación en Ciencias Biomédicas de la Provincia de Cádiz (INiBICA), Hospital Universitario Puerta del Mar, Cádiz, Spain.
  • Alcalde-Estévez E; Department of Endocrinology and Metabolism, University Hospital Puerta del Mar, Cádiz, Spain.
  • Gómez-Jaramillo L; Department of Metabolism and Cell Signaling, Instituto de Investigaciones Biomédicas Alberto Sols (IIBm) (CSIC/UAM), Madrid, Spain.
  • Iturregui M; Research Unit, Instituto de Investigación e Innovación en Ciencias Biomédicas de la Provincia de Cádiz (INiBICA), Hospital Universitario Puerta del Mar, Cádiz, Spain.
  • Sánchez-Fernández EM; Department of Endocrinology and Metabolism, University Hospital Puerta del Mar, Cádiz, Spain.
  • García Fernández JM; Research Unit, Instituto de Investigación e Innovación en Ciencias Biomédicas de la Provincia de Cádiz (INiBICA), Hospital Universitario Puerta del Mar, Cádiz, Spain.
  • Ortiz Mellet C; Department of Endocrinology and Metabolism, University Hospital Puerta del Mar, Cádiz, Spain.
  • Campos-Caro A; Departamento de Química Orgánica, Facultad de Química, Universidad de Sevilla, Sevilla, Spain.
  • López-Tinoco C; Instituto de Investigaciones Químicas (IIQ), CSIC - Universidad de Sevilla, Sevilla, Spain.
  • Aguilar-Diosdado M; Departamento de Química Orgánica, Facultad de Química, Universidad de Sevilla, Sevilla, Spain.
  • Valverde ÁM; Research Unit, Instituto de Investigación e Innovación en Ciencias Biomédicas de la Provincia de Cádiz (INiBICA), Hospital Universitario Puerta del Mar, Cádiz, Spain.
  • Arroba AI; Área Genética, Dpto. Biomedicina Biotecnología y Salud Pública, Universidad de Cádiz, Cádiz, Spain.
Front Immunol ; 12: 632132, 2021.
Article en En | MEDLINE | ID: mdl-33815384
Diabetic retinopathy (DR) is one of the most common complications of Diabetes Mellitus (DM) and is directly associated with inflammatory processes. Currently, neuro-inflammation is considered an early event in DR and proceeds via microglia polarization. A hallmark of DR is the presence of retinal reactive gliosis. Here we report the beneficial effect of (SS,1R)-1-docecylsulfiny-5N,6O-oxomethylidenenojirimycin ((Ss)-DS-ONJ), a member of the sp2-iminosugar glycolipid (sp2-IGL) family, by decreasing iNOS and inflammasome activation in Bv.2 microglial cells exposed to pro-inflammatory stimuli. Moreover, pretreatment with (Ss)-DS-ONJ increased Heme-oxygenase (HO)-1 as well as interleukin 10 (IL10) expression in LPS-stimulated microglial cells, thereby promoting M2 (anti-inflammatory) response by the induction of Arginase-1. The results strongly suggest that this is the likely molecular mechanism involved in the anti-inflammatory effects of (SS)-DS-ONJ in microglia. (SS)-DS-ONJ further reduced gliosis in retinal explants from type 1 diabetic BB rats, which is consistent with the enhanced M2 response. In conclusion, targeting microglia polarization dynamics in M2 status by compounds with anti-inflammatory activities offers promising therapeutic interventions at early stages of DR.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Sulfóxidos / Glucolípidos / Retinopatía Diabética / Antiinflamatorios Límite: Animals Idioma: En Revista: Front Immunol Año: 2021 Tipo del documento: Article País de afiliación: España

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Sulfóxidos / Glucolípidos / Retinopatía Diabética / Antiinflamatorios Límite: Animals Idioma: En Revista: Front Immunol Año: 2021 Tipo del documento: Article País de afiliación: España