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Targeting the nucleotide salvage factor DNPH1 sensitizes BRCA-deficient cells to PARP inhibitors.
Fugger, Kasper; Bajrami, Ilirjana; Silva Dos Santos, Mariana; Young, Sarah Jane; Kunzelmann, Simone; Kelly, Geoff; Hewitt, Graeme; Patel, Harshil; Goldstone, Robert; Carell, Thomas; Boulton, Simon J; MacRae, James; Taylor, Ian A; West, Stephen C.
Afiliación
  • Fugger K; The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK. stephen.west@crick.ac.uk kasper.fugger@crick.ac.uk.
  • Bajrami I; The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
  • Silva Dos Santos M; The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
  • Young SJ; The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
  • Kunzelmann S; The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
  • Kelly G; MRC Biomedical NMR Centre, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
  • Hewitt G; The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
  • Patel H; The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
  • Goldstone R; The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
  • Carell T; Faculty of Chemistry and Pharmacy, Ludwig-Maximilians-Universität München, Butenandtstrasse 5-13, Building F, 81377 Munich, Germany.
  • Boulton SJ; The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
  • MacRae J; The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
  • Taylor IA; The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
  • West SC; The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK. stephen.west@crick.ac.uk kasper.fugger@crick.ac.uk.
Science ; 372(6538): 156-165, 2021 04 09.
Article en En | MEDLINE | ID: mdl-33833118

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Proteínas Proto-Oncogénicas / Inhibidores de Poli(ADP-Ribosa) Polimerasas / Antineoplásicos / N-Glicosil Hidrolasas Límite: Humans Idioma: En Revista: Science Año: 2021 Tipo del documento: Article

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Proteínas Proto-Oncogénicas / Inhibidores de Poli(ADP-Ribosa) Polimerasas / Antineoplásicos / N-Glicosil Hidrolasas Límite: Humans Idioma: En Revista: Science Año: 2021 Tipo del documento: Article