Protein phosphatases in the RNAPII transcription cycle: erasers, sculptors, gatekeepers, and potential drug targets.

Cossa, Giacomo; Parua, Pabitra K; Eilers, Martin; Fisher, Robert P

Cossa, Giacomo; Parua, Pabitra K; Eilers, Martin; Fisher, Robert P.

Afiliación

Cossa G; Department of Biochemistry and Molecular Biology, Biocenter, University of Würzburg, 97074 Würzburg, Germany.
Parua PK; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Eilers M; Department of Biochemistry and Molecular Biology, Biocenter, University of Würzburg, 97074 Würzburg, Germany.
Fisher RP; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.

Genes Dev ; 35(9-10): 658-676, 2021 05 01.

Article en En | MEDLINE | ID: mdl-33888562

Asunto(s)

Fosfoproteínas Fosfatasas/metabolismo; ARN Polimerasa II/genética; Transcripción Genética/genética; Animales; Sistemas de Liberación de Medicamentos; Humanos; Fosfoproteínas Fosfatasas/genética

Palabras clave

RNA polymerase II (RNAPII); RNAPII C-terminal domain (CTD); cyclin-dependent kinases (CDKs); phosphoprotein phosphatases; promoter-proximal pausing; protein phosphatase 1 (PP1); protein phosphatase 2A (PP2A); protein phosphatase 4 (PP4); protein phosphorylation

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Transcripción Genética / ARN Polimerasa II / Fosfoproteínas Fosfatasas Límite: Animals / Humans Idioma: En Revista: Genes Dev Asunto de la revista: BIOLOGIA MOLECULAR Año: 2021 Tipo del documento: Article País de afiliación: Alemania

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