In Silico, In Vitro, and In Vivo Evaluation of Precipitation Inhibitors in Supersaturated Lipid-Based Formulations of Venetoclax.

Koehl, Niklas J; Henze, Laura J; Bennett-Lenane, Harriet; Faisal, Waleed; Price, Daniel J; Holm, René; Kuentz, Martin; Griffin, Brendan T

In Silico, In Vitro, and In Vivo Evaluation of Precipitation Inhibitors in Supersaturated Lipid-Based Formulations of Venetoclax.

Koehl, Niklas J; Henze, Laura J; Bennett-Lenane, Harriet; Faisal, Waleed; Price, Daniel J; Holm, René; Kuentz, Martin; Griffin, Brendan T.

Afiliación

Koehl NJ; School of Pharmacy, University College Cork, College Road, T12 YN60 Cork, Ireland.
Henze LJ; Drug Product Development, Janssen Research and Development, Johnson & Johnson, Turnhoutseweg 30, 2340 Beerse, Belgium.
Bennett-Lenane H; School of Pharmacy, University College Cork, College Road, T12 YN60 Cork, Ireland.
Faisal W; Analytical Development, Janssen Research and Development, Johnson & Johnson, Turnhoutseweg 30, 2340 Beerse, Belgium.
Price DJ; School of Pharmacy, University College Cork, College Road, T12 YN60 Cork, Ireland.
Holm R; School of Pharmacy, University College Cork, College Road, T12 YN60 Cork, Ireland.
Kuentz M; Faculty of Pharmacy, Minia University, Minia, Egypt.
Griffin BT; Merck KGaA, Frankfurter Str. 250, 64293 Darmstadt, Germany.

Mol Pharm ; 18(6): 2174-2188, 2021 06 07.

Article en En | MEDLINE | ID: mdl-33890794

Asunto(s)

Compuestos Bicíclicos Heterocíclicos con Puentes/química; Composición de Medicamentos/métodos; Excipientes/química; Lípidos/química; Sulfonamidas/química; Administración Oral; Animales; Disponibilidad Biológica; Precipitación Química; Química Farmacéutica; Simulación por Computador; Desarrollo de Medicamentos; Masculino; Modelos Animales; Modelos Químicos; Solubilidad; Sus scrofa

Palabras clave

SEDDS; SMEDDS; SNEDDS; lipid based formulation; lipid suspension; polymers; precipitation inhibitor; super-SMEDDS; super-SNEDDS; supersaturating drug delivery systems; supersaturation; venetoclax

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Sulfonamidas / Compuestos Bicíclicos Heterocíclicos con Puentes / Composición de Medicamentos / Excipientes / Lípidos Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Mol Pharm Asunto de la revista: BIOLOGIA MOLECULAR / FARMACIA / FARMACOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Irlanda

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