A trio of quinoline-isoniazid-phthalimide with promising antiplasmodial potential: Synthesis, in-vitro evaluation and heme-polymerization inhibition studies.
Bioorg Med Chem
; 39: 116159, 2021 06 01.
Article
en En
| MEDLINE
| ID: mdl-33895706
ABSTRACT
Quinoline-isoniazid-phthalimide triads have been synthesised to assess their antiplasmodial efficacy and cytotoxicity against chloroquine-resistant W2 strain of P. falciparum and Vero cells, respectively. Most of the synthesized compounds displayed IC50 in lower nM range and appeared to be approximately five to twelve fold more active than chloroquine. Heme-binding studies were also carried out to delineate the mode of action. The promising compounds with IC50s in range of 11-30 nM and selectivity index >2800, may act as promising template for the design of new antiplasmodials.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Ftalimidas
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Plasmodium falciparum
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Quinolinas
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Polimerizacion
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Hemo
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Isoniazida
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Antimaláricos
Límite:
Animals
Idioma:
En
Revista:
Bioorg Med Chem
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2021
Tipo del documento:
Article
País de afiliación:
India