AAs, amino acids; ACT, amino Acid/Choline Transporter; AP, adaptor protein; APC, amino acid-polyamine-organocation; Arg, arginine; Arrestins; Arts, arrestin­related trafficking adaptors; Asp, aspartic acid; Aspergilli; Biotechnology; C, carbon; C-terminus, carboxyl-terminus; Cell factories; Conformational changes; Cu, copper; DUBs, deubiquitinating enzymes; EMCs, eisosome membrane compartments; ER, endoplasmic reticulum; ESCRT, endosomal sorting complex required for transport; Endocytic signals; Endocytosis; Fe, iron; Fungi; GAAC, general amino acid control; Glu, glutamic acid; H+, proton; IF, inward-facing; LAT, L-type Amino acid Transporter; LID, loop Interaction Domain; Lys, lysine; MCCs, membrane compartments containing the arginine permease Can1; MCCs/eisosomes; MCPs, membrane compartments of Pma1; MFS, major facilitator superfamily; MVB, multi vesicular bodies; Met, methionine; Metabolism; Mn, manganese; N, nitrogen; N-terminus, amino-terminus; NAT, nucleobase Ascorbate Transporter; NCS1, nucleobase/Cation Symporter 1; NCS2, nucleobase cation symporter family 2; NH4+, ammonium; Nutrient transporters; OF, outward-facing; PEST, proline (P), glutamic acid (E), serine (S), and threonine (T); PM, plasma membrane; PVE, prevacuolar endosome; Saccharomyces cerevisiae; Signaling pathways; Structure-function; TGN, trans-Golgi network; TMSs, transmembrane segments; TORC1, target of rapamycin complex 1; TRY, titer, rate and yield; Trp, tryptophan; Tyr, tyrosine; Ub, ubiquitin; Ubiquitylation; VPS, vacuolar protein sorting; W/V, weight per volume; YAT, yeast Amino acid Transporter; Zn, Zinc; fAATs, fungal AA transporters