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Phenanthrene alters the electrical activity of atrial and ventricular myocytes of a polar fish, the Navaga cod.
Abramochkin, Denis V; Kompella, Shiva N; Shiels, Holly A.
Afiliación
  • Abramochkin DV; Department of Human and Animal Physiology, Lomonosov Moscow State University, Leninskiye gory, 1, 12, Moscow, 119234, Russia; Laboratory of Cardiac Electrophysiology, National Medical Research Center for Cardiology, 3rd Cherepkovskaya, 15a, Moscow, Russia; Department of Physiology, Pirogov Russian National Research Medical University, Ostrovityanova str., 1, Moscow, Russia; Ural Federal University, 19 Mira Street, 620002 Ekaterinburg, Russia.
  • Kompella SN; Faculty of Biology, Medicine and Health, Core Technology Facility, University of Manchester, 46 Grafton Street, Manchester M13 9NT, UK.
  • Shiels HA; Faculty of Biology, Medicine and Health, Core Technology Facility, University of Manchester, 46 Grafton Street, Manchester M13 9NT, UK. Electronic address: holly.shiels@manchester.ac.uk.
Aquat Toxicol ; 235: 105823, 2021 Jun.
Article en En | MEDLINE | ID: mdl-33906022
ABSTRACT
Oil and gas exploration in the Arctic can result in the release of polycyclic aromatic hydrocarbons (PAHs) into relatively pristine environments. Following the recent spill of approximately 17 500 tonnes of diesel fuel in Norilsk, Russia, May 2020, our study focussed on the effects of phenanthrene, a low molecular weight PAH found in diesel and crude oil, on the isolated atrial and ventricular myocytes from the heart of the polar teleost, the Navaga cod (Eleginus nawaga). Acute exposure to phenanthrene in navaga cardiomyocytes caused significant action potential (AP) prolongation, confirming the proarrhythmic effects of this pollutant. We show AP prolongation was due to potent inhibition of the main repolarising current, IKr, with an IC50 value of ~2 µM. We also show a potent inhibitory effect (~55%) of 1 µM phenanthrene on the transient IKr currents that protects the heart from early-after-depolarizations and arrhythmias. These data, along with more minor effects on inward sodium (INa) (~17% inhibition at 10 µM) and calcium (ICa) (~17% inhibition at 30 µM) currents, and no effects on inward rectifier (IK1 and IKAch) currents, demonstrate the cardiotoxic effects exerted by phenanthrene on the atrium and ventricle of navaga cod. Moreover, we report the first data that we are aware of on the impact of phenanthrene on atrial myocyte function in any fish species.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Fenantrenos / Contaminantes Químicos del Agua / Miocitos Cardíacos / Gadiformes Límite: Animals Idioma: En Revista: Aquat Toxicol Asunto de la revista: BIOLOGIA / TOXICOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Rusia

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Fenantrenos / Contaminantes Químicos del Agua / Miocitos Cardíacos / Gadiformes Límite: Animals Idioma: En Revista: Aquat Toxicol Asunto de la revista: BIOLOGIA / TOXICOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Rusia