TET2 Drives 5hmc Marking of GATA6 and Epigenetically Defines Pancreatic Ductal Adenocarcinoma Transcriptional Subtypes.

Eyres, Michael; Lanfredini, Simone; Xu, Haonan; Burns, Adam; Blake, Andrew; Willenbrock, Frances; Goldin, Robert; Hughes, Daniel; Hughes, Sophie; Thapa, Asmita; Vavoulis, Dimitris; Hubert, Aline; D'Costa, Zenobia; Sabbagh, Ahmad; Abraham, Aswin G; Blancher, Christine; Jones, Stephanie; Verrill, Clare; Silva, Michael; Soonawalla, Zahir; Maughan, Timothy; Schuh, Anna; Mukherjee, Somnath; O'Neill, Eric

Eyres, Michael; Lanfredini, Simone; Xu, Haonan; Burns, Adam; Blake, Andrew; Willenbrock, Frances; Goldin, Robert; Hughes, Daniel; Hughes, Sophie; Thapa, Asmita; Vavoulis, Dimitris; Hubert, Aline; D'Costa, Zenobia; Sabbagh, Ahmad; Abraham, Aswin G; Blancher, Christine; Jones, Stephanie; Verrill, Clare; Silva, Michael; Soonawalla, Zahir; Maughan, Timothy; Schuh, Anna; Mukherjee, Somnath; O'Neill, Eric.

Afiliación

Eyres M; Department of Oncology, University of Oxford, Oxford, UK.
Lanfredini S; Department of Oncology, University of Oxford, Oxford, UK.
Xu H; Department of Oncology, University of Oxford, Oxford, UK.
Burns A; Department of Oncology, University of Oxford, Oxford, UK.
Blake A; Department of Oncology, University of Oxford, Oxford, UK.
Willenbrock F; Department of Oncology, University of Oxford, Oxford, UK.
Goldin R; Centre for Pathology, Imperial College, London, United Kingdom.
Hughes D; Department of Oncology, University of Oxford, Oxford, UK; Department of Hepatobiliary and Pancreatic Surgery, Oxford University Hospitals National Health Service Foundation Trust, Oxford, United Kingdom.
Hughes S; Department of Oncology, University of Oxford, Oxford, UK.
Thapa A; Department of Oncology, University of Oxford, Oxford, UK.
Vavoulis D; Department of Oncology, University of Oxford, Oxford, UK.
Hubert A; Department of Oncology, University of Oxford, Oxford, UK.
D'Costa Z; Department of Oncology, University of Oxford, Oxford, UK.
Sabbagh A; Department of Oncology, University of Oxford, Oxford, UK.
Abraham AG; Department of Oncology, University of Oxford, Oxford, UK.
Blancher C; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
Jones S; Oxford Radcliffe Biobank, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom.
Verrill C; Nuffield Department of Surgical Sciences and Oxford National Institute for Health Research Biomedical Research Centre, University of Oxford, Oxford, United Kingdom.
Silva M; Department of Hepatobiliary and Pancreatic Surgery, Oxford University Hospitals National Health Service Foundation Trust, Oxford, United Kingdom.
Soonawalla Z; Department of Hepatobiliary and Pancreatic Surgery, Oxford University Hospitals National Health Service Foundation Trust, Oxford, United Kingdom.
Maughan T; Department of Oncology, University of Oxford, Oxford, UK.
Schuh A; Department of Oncology, University of Oxford, Oxford, UK.
Mukherjee S; Department of Oncology, University of Oxford, Oxford, UK. Electronic address: somnath.mukherjee@ouh.nhs.uk.
O'Neill E; Department of Oncology, University of Oxford, Oxford, UK. Electronic address: eric.oneill@oncology.ox.ac.uk.

Gastroenterology ; 161(2): 653-668.e16, 2021 08.

Article en En | MEDLINE | ID: mdl-33915173

Asunto(s)

5-Metilcitosina/análogos & derivados; Biomarcadores de Tumor/genética; Carcinoma Ductal Pancreático/genética; Metilación de ADN; Proteínas de Unión al ADN/metabolismo; Dioxigenasas/metabolismo; Epigénesis Genética; Factor de Transcripción GATA6/genética; Neoplasias Pancreáticas/genética; Transcripción Genética; 5-Metilcitosina/metabolismo; Animales; Protocolos de Quimioterapia Combinada Antineoplásica/farmacología; Ácido Ascórbico/farmacología; Biomarcadores de Tumor/metabolismo; Carcinoma Ductal Pancreático/tratamiento farmacológico; Carcinoma Ductal Pancreático/enzimología; Carcinoma Ductal Pancreático/patología; Diferenciación Celular; Línea Celular Tumoral; Metilación de ADN/efectos de los fármacos; Proteínas de Unión al ADN/genética; Dioxigenasas/genética; Epigénesis Genética/efectos de los fármacos; Epigenoma; Epigenómica; Factor de Transcripción GATA6/metabolismo; Perfilación de la Expresión Génica; Regulación Neoplásica de la Expresión Génica; Humanos; Metformina/farmacología; Ratones Desnudos; Ratones Transgénicos; Neoplasias Pancreáticas/tratamiento farmacológico; Neoplasias Pancreáticas/enzimología; Neoplasias Pancreáticas/patología; Estudios Retrospectivos; Proteína Smad4/genética; Proteína Smad4/metabolismo; Transcripción Genética/efectos de los fármacos; Transcriptoma; Vía de Señalización Wnt/genética; Ensayos Antitumor por Modelo de Xenoinjerto

Palabras clave

Epigenetics; GATA6; Pancreatic Cancer; SMAD4; TET2

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Transcripción Genética / Biomarcadores de Tumor / Metilación de ADN / Carcinoma Ductal Pancreático / 5-Metilcitosina / Epigénesis Genética / Dioxigenasas / Proteínas de Unión al ADN / Factor de Transcripción GATA6 Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Gastroenterology Año: 2021 Tipo del documento: Article País de afiliación: Reino Unido

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