Social isolation impairs the prefrontal-nucleus accumbens circuit subserving social recognition in mice.
Cell Rep
; 35(6): 109104, 2021 05 11.
Article
en En
| MEDLINE
| ID: mdl-33979617
ABSTRACT
Although medial prefrontal cortex (mPFC) is known to play important roles in social behaviors, how early social experiences affect the mPFC and its subcortical circuit remains unclear. We report that mice singly housed (SH) for 8 weeks after weaning show a social recognition deficit, even after 4 weeks of resocialization. In SH mice, prefrontal infralimbic (IL) neurons projecting to the shell region of nucleus accumbens (NAcSh) show decreased excitability compared with group-housed (GH) mice. NAcSh-projecting IL neurons are activated when GH mice encounter a familiar conspecific, which is not observed in SH mice. Chemogenetic inhibition of NAcSh-projecting IL neurons in normal mice impairs social recognition without affecting social preference, whereas activation of these neurons reverses social recognition deficit in SH mice. Our findings demonstrate that early social experience critically affects mPFC IL-NAcSh projection, the activation of which is required for social recognition by encoding information for social familiarity.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Conducta Social
/
Aislamiento Social
/
Corteza Prefrontal
/
Reconocimiento en Psicología
/
Núcleo Accumbens
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Cell Rep
Año:
2021
Tipo del documento:
Article