Your browser doesn't support javascript.
loading
Terahertz time-domain spectroscopy for powder compact porosity and pore shape measurements: An error analysis of the anisotropic bruggeman model.
Anuschek, Moritz; Bawuah, Prince; Zeitler, J Axel.
Afiliación
  • Anuschek M; Department of Chemical Engineering and Biotechnology, University of Cambridge, Philippa Fawcett Drive, CB3 0AS Cambridge, UK.
  • Bawuah P; Department of Pharmacy, Pharmaceutical Technology and Biopharmaceutics, Ludwig-Maximilians-University, Butenandtstraße, Munich, Germany.
  • Zeitler JA; Department of Chemical Engineering and Biotechnology, University of Cambridge, Philippa Fawcett Drive, CB3 0AS Cambridge, UK.
Int J Pharm X ; 3: 100079, 2021 Dec.
Article en En | MEDLINE | ID: mdl-34027385
Palabras clave
<ns0:math> <msub> <mover> <mi>ϵ</mi> <mo>˜</mo> </mover> <mi>eff</mi> </msub> </math>, Effective complex dielectric permittivity; <ns0:math> <msub> <mover> <mi>ϵ</mi> <mo>˜</mo> </mover> <mi>s</mi> </msub> </math>, Complex dielectric permittivity of the solid fract; <ns0:math> <mover> <mi>n</mi> <mo>˜</mo> </mover> </math>, Complex refractive index; AB-EMA, Anisotropic Bruggemen model; API, Active pharmaceutical ingredient; Anisotropy; Bruggeman model; D, Tablet diameter; Density distribution; H, Tablet thickness; Ibu, Ibuprofen formulation; L, Depolarisation factor; L1, Depolarisation factor at the lowest porosity; Lac, Lactose; Lfit, Estimation of the depolarisation factor based on a fitting model; Ll/u, Lower/upper bound of the depolarisation factor; Lmax/min, Maximal/minimal depolarisation factor in the simulation of a tablet set; M, Tablet mass; MCC, Microcrystalline cellulose; Pharmaceutical tablet; Pore structure; RMSE, Root-mean squared error; THz-TDS, Terahertz time-domain spectroscopy; Terahertz; a1, Gradient of the depolarisation factor as a function of porosity; a2, Y-intercept of the depolarisation factor as a function of porosity; c, Speed of light; f, Porosity; f1, Lowest porosity in a set of tablets; n, Refractive index; neff, 1, Effective refractive index at the lowest porosity; neff, Effective refractive index; neff, l/u, Lower/upper Wiener bound for neff; neff, l/u, Lower/upper margin for ns; ns, Intrinsic refractive index of the solid fraction; ns, c, ns estimated with accounting for absorption; ns, fit, Estimation of the intrinsic refractive index based on a fitting model; p, Polar axis of a spheroid, parallel to the wavevector; q, r, Equatorial axes of a spheroid, perpendicular to the wavevector; tablename Str, Starch; &#945;eff, Effective absorption coefficient; &#954;, Extinction coefficient; &#954;eff, Effective extinction coefficient

Texto completo: 1 Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Int J Pharm X Año: 2021 Tipo del documento: Article País de afiliación: Reino Unido

Texto completo: 1 Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Int J Pharm X Año: 2021 Tipo del documento: Article País de afiliación: Reino Unido