Terahertz time-domain spectroscopy for powder compact porosity and pore shape measurements: An error analysis of the anisotropic bruggeman model.
Int J Pharm X
; 3: 100079, 2021 Dec.
Article
en En
| MEDLINE
| ID: mdl-34027385
<ns0:math> <msub> <mover> <mi>ϵ</mi> <mo>Ë</mo> </mover> <mi>eff</mi> </msub> </math>, Effective complex dielectric permittivity; <ns0:math> <msub> <mover> <mi>ϵ</mi> <mo>Ë</mo> </mover> <mi>s</mi> </msub> </math>, Complex dielectric permittivity of the solid fract; <ns0:math> <mover> <mi>n</mi> <mo>Ë</mo> </mover> </math>, Complex refractive index; AB-EMA, Anisotropic Bruggemen model; API, Active pharmaceutical ingredient; Anisotropy; Bruggeman model; D, Tablet diameter; Density distribution; H, Tablet thickness; Ibu, Ibuprofen formulation; L, Depolarisation factor; L1, Depolarisation factor at the lowest porosity; Lac, Lactose; Lfit, Estimation of the depolarisation factor based on a fitting model; Ll/u, Lower/upper bound of the depolarisation factor; Lmax/min, Maximal/minimal depolarisation factor in the simulation of a tablet set; M, Tablet mass; MCC, Microcrystalline cellulose; Pharmaceutical tablet; Pore structure; RMSE, Root-mean squared error; THz-TDS, Terahertz time-domain spectroscopy; Terahertz; a1, Gradient of the depolarisation factor as a function of porosity; a2, Y-intercept of the depolarisation factor as a function of porosity; c, Speed of light; f, Porosity; f1, Lowest porosity in a set of tablets; n, Refractive index; neff, 1, Effective refractive index at the lowest porosity; neff, Effective refractive index; neff, l/u, Lower/upper Wiener bound for neff; neff, l/u, Lower/upper margin for ns; ns, Intrinsic refractive index of the solid fraction; ns, c, ns estimated with accounting for absorption; ns, fit, Estimation of the intrinsic refractive index based on a fitting model; p, Polar axis of a spheroid, parallel to the wavevector; q, r, Equatorial axes of a spheroid, perpendicular to the wavevector; tablename Str, Starch; αeff, Effective absorption coefficient; κ, Extinction coefficient; κeff, Effective extinction coefficient
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Base de datos:
MEDLINE
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Int J Pharm X
Año:
2021
Tipo del documento:
Article
País de afiliación:
Reino Unido