Genetic Polymorphisms Related to VO2max Adaptation Are Associated With Elite Rugby Union Status and Competitive Marathon Performance.
Int J Sports Physiol Perform
; 16(12): 1858-1864, 2021 12 01.
Article
en En
| MEDLINE
| ID: mdl-34088882
ABSTRACT
PURPOSE:
Genetic polymorphisms have been associated with the adaptation to training in maximal oxygen uptake (VËO2max). However, the genotype distribution of selected polymorphisms in athletic cohorts is unknown, with their influence on performance characteristics also undetermined. This study investigated whether the genotype distributions of 3 polymorphisms previously associated with VËO2max training adaptation are associated with elite athlete status and performance characteristics in runners and rugby athletes, competitors for whom aerobic metabolism is important.METHODS:
Genomic DNA was collected from 732 men including 165 long-distance runners, 212 elite rugby union athletes, and 355 nonathletes. Genotype and allele frequencies of PRDM1 rs10499043 C/T, GRIN3A rs1535628 G/A, and KCNH8 rs4973706 T/C were compared between athletes and nonathletes. Personal-best marathon times in runners, as well as in-game performance variables and playing position, of rugby athletes were analyzed according to genotype.RESULTS:
Runners with PRDM1 T alleles recorded marathon times â¼3 minutes faster than CC homozygotes (022755 [000732] h vs 023103 [000824] h, P = .023). Rugby athletes had 1.57 times greater odds of possessing the KCNH8 TT genotype than nonathletes (65.5% vs 54.7%, χ2 = 6.494, P = .013). No other associations were identified.CONCLUSIONS:
This study is the first to demonstrate that polymorphisms previously associated with VËO2max training adaptations in nonathletes are also associated with marathon performance (PRDM1) and elite rugby union status (KCNH8). The genotypes and alleles previously associated with superior endurance-training adaptation appear to be advantageous in long-distance running and achieving elite status in rugby union.Palabras clave
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Base de datos:
MEDLINE
Asunto principal:
Carrera
/
Rendimiento Atlético
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Límite:
Humans
/
Male
Idioma:
En
Revista:
Int J Sports Physiol Perform
Asunto de la revista:
FISIOLOGIA
/
MEDICINA ESPORTIVA
Año:
2021
Tipo del documento:
Article