DNA-Based Synthetic Growth Factor Surrogates with Fine-Tuned Agonism*.
Angew Chem Int Ed Engl
; 60(42): 22745-22752, 2021 10 11.
Article
en En
| MEDLINE
| ID: mdl-34142433
ABSTRACT
Designing synthetic surrogates of functional proteins is an important, albeit challenging, task in the field of chemistry. A strategy toward the design of synthetic agonists for growth factor or cytokine receptors that elicit a desired signal activity has been in high demand, as such ligands hold great promise as safer and more effective therapeutics. In the present study, we used a DNA aptamer as a building block and described the strategy-guided design of a synthetic receptor agonist with fine-tuned agonism. The developed synthetic partial agonist can regulate therapeutically relevant cellular activities by eliciting fine-tuned receptor signaling.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Receptores de Citocinas
/
Péptidos y Proteínas de Señalización Intercelular
/
Aptámeros de Nucleótidos
Límite:
Humans
Idioma:
En
Revista:
Angew Chem Int Ed Engl
Año:
2021
Tipo del documento:
Article
País de afiliación:
Japón