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Comparison of genome-wide gene expression profiling by RNA Sequencing versus microarray in bronchial biopsies of COPD patients before and after inhaled corticosteroid treatment: does it provide new insights?
Ditz, Benedikt; Boekhoudt, Jeunard G; Aliee, Hananeh; Theis, Fabian J; Nawijn, Martijn; Brandsma, Corry-Anke; Hiemstra, Pieter S; Timens, Wim; Tew, Gaik W; Grimbaldeston, Michele A; Neighbors, Margaret; Guryev, Victor; van den Berge, Maarten; Faiz, Alen.
Afiliación
  • Ditz B; Dept of Pulmonary Diseases, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  • Boekhoudt JG; University of Groningen, University Medical Center Groningen, GRIAC (Groningen Research Institute for Asthma and COPD), Groningen, The Netherlands.
  • Aliee H; Co-first authors.
  • Theis FJ; University of Groningen, University Medical Center Groningen, GRIAC (Groningen Research Institute for Asthma and COPD), Groningen, The Netherlands.
  • Nawijn M; Dept of Pathology and Medical Biology, section Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  • Brandsma CA; Co-first authors.
  • Hiemstra PS; Institute of Computational Biology, Helmholtz Centre, Munich, Germany.
  • Timens W; Institute of Computational Biology, Helmholtz Centre, Munich, Germany.
  • Tew GW; Dept of Mathematics, Technical University of Munich, Munich, Germany.
  • Grimbaldeston MA; University of Groningen, University Medical Center Groningen, GRIAC (Groningen Research Institute for Asthma and COPD), Groningen, The Netherlands.
  • Neighbors M; Dept of Pathology and Medical Biology, section Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  • Guryev V; University of Groningen, University Medical Center Groningen, GRIAC (Groningen Research Institute for Asthma and COPD), Groningen, The Netherlands.
  • van den Berge M; Dept of Pathology and Medical Biology, section Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  • Faiz A; Dept of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands.
ERJ Open Res ; 7(2)2021 Apr.
Article en En | MEDLINE | ID: mdl-34164552
ABSTRACT
More DEGs are detected by RNA-Seq than microarrays in COPD lung biopsies and are associated with immunological pathways. Performing bulk tissue cell-type deconvolution in microarray lung samples, using the SVR method, reflects RNA-Seq results. https//bit.ly/2N8sY3s.
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Texto completo: 1 Base de datos: MEDLINE Idioma: En Revista: ERJ Open Res Año: 2021 Tipo del documento: Article País de afiliación: Países Bajos
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de datos: MEDLINE Idioma: En Revista: ERJ Open Res Año: 2021 Tipo del documento: Article País de afiliación: Países Bajos