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White matter plasticity in healthy older adults: The effects of aerobic exercise.
Mendez Colmenares, Andrea; Voss, Michelle W; Fanning, Jason; Salerno, Elizabeth A; Gothe, Neha P; Thomas, Michael L; McAuley, Edward; Kramer, Arthur F; Burzynska, Agnieszka Z.
Afiliación
  • Mendez Colmenares A; Department of Human Development and Family Studies/Molecular, Cellular and Integrative Neurosciences, Colorado State University, Fort Collins, CO, 80523, United States; Department of Psychology/Molecular, Cellular and Integrative Neurosciences, Colorado State University, Fort Collins, CO, 80523, Uni
  • Voss MW; Department of Psychological and Brain Sciences, University of Iowa, Iowa City, IA, 52242, United States.
  • Fanning J; Department of Health and Exercise Sciences, Wake Forest University, Winston-Salem, NC, 27109, United States.
  • Salerno EA; Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine in St. Louis, St. Louis, MO, 63130, United States.
  • Gothe NP; Department of Kinesiology and Community Health, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, United States.
  • Thomas ML; Department of Psychology/Molecular, Cellular and Integrative Neurosciences, Colorado State University, Fort Collins, CO, 80523, United States.
  • McAuley E; Department of Kinesiology and Community Health, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, United States.
  • Kramer AF; Department of Kinesiology and Community Health, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, United States; Department of Psychology, Northeastern University, Boston, MA, 02115, United States.
  • Burzynska AZ; Department of Psychology, Northeastern University, Boston, MA, 02115, United States. Electronic address: agaburza@colostate.edu.
Neuroimage ; 239: 118305, 2021 10 01.
Article en En | MEDLINE | ID: mdl-34174392
White matter deterioration is associated with cognitive impairment in healthy aging and Alzheimer's disease. It is critical to identify interventions that can slow down white matter deterioration. So far, clinical trials have failed to demonstrate the benefits of aerobic exercise on the adult white matter using diffusion Magnetic Resonance Imaging. Here, we report the effects of a 6-month aerobic walking and dance interventions (clinical trial NCT01472744) on white matter integrity in healthy older adults (n = 180, 60-79 years) measured by changes in the ratio of calibrated T1- to T2-weighted images (T1w/T2w). Specifically, the aerobic walking and social dance interventions resulted in positive changes in the T1w/T2w signal in late-myelinating regions, as compared to widespread decreases in the T1w/T2w signal in the active control. Notably, in the aerobic walking group, positive change in the T1w/T2w signal correlated with improved episodic memory performance. Lastly, intervention-induced increases in cardiorespiratory fitness did not correlate with change in the T1w/T2w signal. Together, our findings suggest that white matter regions that are vulnerable to aging retain some degree of plasticity that can be induced by aerobic exercise training. In addition, we provided evidence that the T1w/T2w signal may be a useful and broadly accessible measure for studying short-term within-person plasticity and deterioration in the adult human white matter.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Imagen por Resonancia Magnética / Ejercicio Físico / Corteza Cerebral / Caminata / Baile / Sustancia Blanca / Capacidad Cardiovascular / Envejecimiento Saludable / Plasticidad Neuronal Tipo de estudio: Clinical_trials / Prognostic_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Neuroimage Asunto de la revista: DIAGNOSTICO POR IMAGEM Año: 2021 Tipo del documento: Article

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Imagen por Resonancia Magnética / Ejercicio Físico / Corteza Cerebral / Caminata / Baile / Sustancia Blanca / Capacidad Cardiovascular / Envejecimiento Saludable / Plasticidad Neuronal Tipo de estudio: Clinical_trials / Prognostic_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Neuroimage Asunto de la revista: DIAGNOSTICO POR IMAGEM Año: 2021 Tipo del documento: Article