Clinical validation of a targeted methylation-based multi-cancer early detection test using an independent validation set.

Klein, E A; Richards, D; Cohn, A; Tummala, M; Lapham, R; Cosgrove, D; Chung, G; Clement, J; Gao, J; Hunkapiller, N; Jamshidi, A; Kurtzman, K N; Seiden, M V; Swanton, C; Liu, M C

Klein, E A; Richards, D; Cohn, A; Tummala, M; Lapham, R; Cosgrove, D; Chung, G; Clement, J; Gao, J; Hunkapiller, N; Jamshidi, A; Kurtzman, K N; Seiden, M V; Swanton, C; Liu, M C.

Afiliación

Klein EA; Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, USA. Electronic address: kleine@ccf.org.
Richards D; The US Oncology Network, Tyler, USA.
Cohn A; The US Oncology Network, Denver, USA.
Tummala M; Mercy Clinic Cancer Center, Springfield, USA.
Lapham R; Spartanburg Regional Healthcare System, Spartanburg, USA.
Cosgrove D; Compass Oncology, Vancouver, Canada.
Chung G; The Christ Hospital Health Network, Cincinnati, USA.
Clement J; Hartford HealthCare Cancer Institute, Hartford, USA.
Gao J; GRAIL, Inc., Menlo Park, USA.
Hunkapiller N; GRAIL, Inc., Menlo Park, USA.
Jamshidi A; GRAIL, Inc., Menlo Park, USA.
Kurtzman KN; GRAIL, Inc., Menlo Park, USA.
Seiden MV; US Oncology Research, The Woodlands, USA.
Swanton C; The Francis Crick Institute, London, UK; University College London Cancer Institute, London, UK.
Liu MC; Mayo Clinic, Rochester, USA.

Ann Oncol ; 32(9): 1167-1177, 2021 09.

Article en En | MEDLINE | ID: mdl-34176681

Asunto(s)

Detección Precoz del Cáncer; Neoplasias; Biomarcadores de Tumor/genética; Metilación de ADN; Humanos; Neoplasias/diagnóstico; Neoplasias/genética; Oncogenes; Estudios Prospectivos

Palabras clave

cancer; cell-free nucleic acids; liquid biopsy; machine learning; methylation; multi-cancer early detection

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Detección Precoz del Cáncer / Neoplasias Tipo de estudio: Clinical_trials / Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Límite: Humans Idioma: En Revista: Ann Oncol Asunto de la revista: NEOPLASIAS Año: 2021 Tipo del documento: Article

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