The tectonigral pathway regulates appetitive locomotion in predatory hunting in mice.
Nat Commun
; 12(1): 4409, 2021 07 20.
Article
en En
| MEDLINE
| ID: mdl-34285209
ABSTRACT
Appetitive locomotion is essential for animals to approach rewards, such as food and prey. The neuronal circuitry controlling appetitive locomotion is unclear. In a goal-directed behavior-predatory hunting, we show an excitatory brain circuit from the superior colliculus (SC) to the substantia nigra pars compacta (SNc) to enhance appetitive locomotion in mice. This tectonigral pathway transmits locomotion-speed signals to dopamine neurons and triggers dopamine release in the dorsal striatum. Synaptic inactivation of this pathway impairs appetitive locomotion but not defensive locomotion. Conversely, activation of this pathway increases the speed and frequency of approach during predatory hunting, an effect that depends on the activities of SNc dopamine neurons. Together, these data reveal that the SC regulates locomotion-speed signals to SNc dopamine neurons to enhance appetitive locomotion in mice.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Conducta Apetitiva
/
Conducta Predatoria
/
Colículos Superiores
/
Porción Compacta de la Sustancia Negra
/
Locomoción
Límite:
Animals
Idioma:
En
Revista:
Nat Commun
Asunto de la revista:
BIOLOGIA
/
CIENCIA
Año:
2021
Tipo del documento:
Article
País de afiliación:
China