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Affinity maturation of SARS-CoV-2 neutralizing antibodies confers potency, breadth, and resilience to viral escape mutations.
Muecksch, Frauke; Weisblum, Yiska; Barnes, Christopher O; Schmidt, Fabian; Schaefer-Babajew, Dennis; Wang, Zijun; C Lorenzi, Julio C; Flyak, Andrew I; DeLaitsch, Andrew T; Huey-Tubman, Kathryn E; Hou, Shurong; Schiffer, Celia A; Gaebler, Christian; Da Silva, Justin; Poston, Daniel; Finkin, Shlomo; Cho, Alice; Cipolla, Melissa; Oliveira, Thiago Y; Millard, Katrina G; Ramos, Victor; Gazumyan, Anna; Rutkowska, Magdalena; Caskey, Marina; Nussenzweig, Michel C; Bjorkman, Pamela J; Hatziioannou, Theodora; Bieniasz, Paul D.
Afiliación
  • Muecksch F; Laboratory of Retrovirology, The Rockefeller University, New York, NY 10065, USA.
  • Weisblum Y; Laboratory of Retrovirology, The Rockefeller University, New York, NY 10065, USA.
  • Barnes CO; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
  • Schmidt F; Laboratory of Retrovirology, The Rockefeller University, New York, NY 10065, USA.
  • Schaefer-Babajew D; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA.
  • Wang Z; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA.
  • C Lorenzi JC; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA.
  • Flyak AI; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
  • DeLaitsch AT; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
  • Huey-Tubman KE; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
  • Hou S; Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01655, USA.
  • Schiffer CA; Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01655, USA.
  • Gaebler C; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA.
  • Da Silva J; Laboratory of Retrovirology, The Rockefeller University, New York, NY 10065, USA.
  • Poston D; Laboratory of Retrovirology, The Rockefeller University, New York, NY 10065, USA.
  • Finkin S; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA.
  • Cho A; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA.
  • Cipolla M; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA.
  • Oliveira TY; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA.
  • Millard KG; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA.
  • Ramos V; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA.
  • Gazumyan A; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA.
  • Rutkowska M; Laboratory of Retrovirology, The Rockefeller University, New York, NY 10065, USA.
  • Caskey M; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA.
  • Nussenzweig MC; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA; Howard Hughes Medical Institute. Electronic address: nussen@mail.rockefeller.edu.
  • Bjorkman PJ; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA. Electronic address: bjorkman@caltech.edu.
  • Hatziioannou T; Laboratory of Retrovirology, The Rockefeller University, New York, NY 10065, USA. Electronic address: thatziio@rockefeller.edu.
  • Bieniasz PD; Laboratory of Retrovirology, The Rockefeller University, New York, NY 10065, USA; Howard Hughes Medical Institute. Electronic address: pbieniasz@rockefeller.edu.
Immunity ; 54(8): 1853-1868.e7, 2021 08 10.
Article en En | MEDLINE | ID: mdl-34331873
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Interacciones Huésped-Patógeno / SARS-CoV-2 / COVID-19 / Afinidad de Anticuerpos / Mutación Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Immunity Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Interacciones Huésped-Patógeno / SARS-CoV-2 / COVID-19 / Afinidad de Anticuerpos / Mutación Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Immunity Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos