Hypotonic-hyporesponsive Episodes After Diphtheria, Tetanus and Acellular Pertussis Vaccination.
Pediatr Infect Dis J
; 40(12): 1122-1126, 2021 12 01.
Article
en En
| MEDLINE
| ID: mdl-34420008
ABSTRACT
BACKGROUND:
Hypotonic-hyporesponsive episode (HHE) after whole cell pertussis vaccination is a known adverse event. Less is known about the risk of HHE after administration of acellular pertussis vaccines.METHODS:
Using parental interviews, this study actively surveyed for HHE among infants after doses 1 and 2 of acellular pertussis vaccine.RESULTS:
We interviewed the parents of 52,531 infants. HHE was reported at a rate of 22.8 per 100,000 doses (95% CI 11.8-39.9) of acellular pertussis vaccine, approximately 45 episodes per 100,000 children.CONCLUSIONS:
These rates are lower than HHE rates reported after whole cell pertussis vaccines and within the range of HHE rates reported in other studies of acellular pertussis vaccines.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Vacunación
/
Vacunas contra Difteria, Tétanos y Tos Ferina Acelular
/
Hipotonía Muscular
Tipo de estudio:
Observational_studies
Límite:
Female
/
Humans
/
Infant
/
Male
Idioma:
En
Revista:
Pediatr Infect Dis J
Asunto de la revista:
DOENCAS TRANSMISSIVEIS
/
PEDIATRIA
Año:
2021
Tipo del documento:
Article