Outcomes in primary cutaneous diffuse large B-cell lymphoma, leg type.
Hematol Oncol
; 39(5): 658-663, 2021 Dec.
Article
en En
| MEDLINE
| ID: mdl-34453851
ABSTRACT
Primary cutaneous diffuse large B-cell lymphoma, leg type (PCDLBCL, LT) is a rare, aggressive lymphoma characterized by skin involvement predominantly in the lower extremities. Immunochemotherapy with or without involved-site radiation therapy (ISRT) is considered standard front-line therapy. Over-expression of PD-L1/PD-L2 is seen in a high proportion of PCDLBCL, LT cases, but efficacy of immune checkpoint inhibitors (ICI) in relapsed/refractory, PCDLBCL, LT has not been thoroughly studied. We conducted a retrospective cohort study of patients diagnosed with PCDLBCL, LT seen at Mayo Clinic from 1 January 2000 to 31 December 2020. Using the Kaplan-Meier method, we calculated progression-free survival, duration of response, and overall survival in patients who received front-line rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) with and without ISRT, and salvage ICI therapy for relapsed/refractory disease. A total of 28 patients with PCDLBCL, LT were identified. The median PFS in patients treated with R-CHOP plus ISRT was 58 months (95% CI 18-112) compared to 14 months (95% CI 5-not reached; p = 0.04) in those treated with R-CHOP without ISRT. The median PFS from salvage ICI therapy was 10 months (95% CI 4-not reached), and median DOR from salvage ICI therapy was 23 months [95% CI 4-26]. R-CHOP with ISRT had a significantly longer median PFS compared to R-CHOP without ISRT as front-line therapy for PCDLBCL, LT. ICIs may have a role in treating relapsed/refractory disease as reasonable activity in heavily pre-treated patients was observed in this study.
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Texto completo:
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Base de datos:
MEDLINE
Asunto principal:
Neoplasias Cutáneas
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Protocolos de Quimioterapia Combinada Antineoplásica
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Linfoma de Células B Grandes Difuso
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Resistencia a Antineoplásicos
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Quimioradioterapia
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Pierna
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Recurrencia Local de Neoplasia
Tipo de estudio:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Hematol Oncol
Año:
2021
Tipo del documento:
Article
País de afiliación:
Estados Unidos