[An update on parathyroid carcinoma]. / Puesta al día: carcinoma paratiroideo.
Rev Med Chil
; 149(3): 399-408, 2021 Mar.
Article
en Es
| MEDLINE
| ID: mdl-34479319
ABSTRACT
Parathyroid carcinoma is a rare malignant disease that presents as a sporadic or familial primary hyperparathyroidism (PHP). The latter is associated with some genetic syndromes. It occurs with equal frequency in both sexes, unlike PHP caused by parathyroid adenoma that is more common in women. It should be suspected in cases of severe hypercalcemia, with high parathyroid hormone levels and a palpable cervical mass. Given the difficulty in distinguishing between parathyroid carcinoma and adenoma prior to the surgery, the diagnosis is often made after parathyroidectomy. The only curative treatment is complete surgical resection with oncologic block resection of the primary tumor to ensure free margins. Adjuvant therapies with chemotherapy or radiation therapy do not modify overall or disease-free survival. Recurrences are common and re-operation of resectable recurrent disease is recommended. The palliative treatment of symptomatic hypercalcemia is crucial in persistent or recurrent disease after surgery since morbidity and mortality are more associated with hypercalcemia than with tumor burden.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Neoplasias de las Paratiroides
/
Hiperparatiroidismo Primario
/
Hipercalcemia
Tipo de estudio:
Diagnostic_studies
/
Etiology_studies
Límite:
Female
/
Humans
/
Male
Idioma:
Es
Revista:
Rev Med Chil
Año:
2021
Tipo del documento:
Article
País de afiliación:
Chile